The patient is taking 200mgs of 5HTP at bedtime. They’re sleeping through the night but continue to have a good deal of pain. I’ll instruct the patient to take an additional 50mgs of 5HTP twice a day with food (lunch and dinner).

Patients who can’t take at bedtime should increase their dose to up a total of 300mgs taken with food.

NOTE- IBS SYMPTOMS SHOULD GO AWAY ONCE YOUR SEROTONIN LEVELS ARE RESTORED. In my practice this usually occurs within 2-3 weeks.

If IBS continues even with 300mgs of 5HTP, then I recommend patients start taking 3 probiotics a day on an empty stomach.

From a longer article by Doctor Rodger Murphree:  A Good Nights Sleep