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HEALTH TIPS WEEKLY - Thursday, April 17, 2008 "News That Keeps You Healthy" ------------------------------------------------------------
Study: Gene variant increases asthma risk CHICAGO, -- U.S. scientists say they've determined a tiny variation in a gene known as CHI3L1 increases one's suscept- ibility to asthma and related medical conditions. University of Chicago Medical Center researchers said the gene variant causes increased blood levels of YKL-40, a biomarker for asthma. A slightly different genetic variation lowers YKL-40 levels and protects against asthma, bronchial hyperrespons- iveness and declines in lung function. Although the original discovery came from a study of a genetically isolated popu- lation, the Hutterites of South Dakota, the researchers were able to confirm the same connections between the CHI3L1 var- iations, YKL-40 levels and asthma susceptibility in three genetically diverse Caucasian populations from Chicago, Mad- ison, Wis., and Freiberg, Germany. "This is exciting because it connects asthma susceptibility to a whole new pathway at the protein and the genetic levels," said Professor Carole Ober, the study's author. "There is a good deal more we need to find out about this connection, but now we know where to look." The findings are reported in the early online edition of the New England Journal of Medicine in advance of the journal's April 17 issue. ------------------------------------------------------------ Breast cancer trial starts with good news ANN ARBOR, Mich., -- U.S. scientists have discovered more about a common cell-to-cell signaling system that has good implications for a breast cancer drug trial just beginning. In the groundbreaking trial, University of Michigan Medical School researchers are combining chemotherapy with a drug that blocks the Notch signaling pathway that helps regulate fetal development and is active in most organ systems throughout a person's life. The aim is to use so-called Notch inhibitors to attack cancer stem cells. But a big con- cern is that the Notch inhibitors, while helping destroy cancer stem cells, might also kill healthy stem cells crit- ical to a patient's survival. However, a recent study cond- ucted by UM Assistant Professor Ivan Maillard and colleagues might allay those fears. The researchers showed that blood- forming stem cells in mice survive when their Notch signal- ing pathway is experimentally blocked. "Our data indicate that normal blood-forming stem cells should not be damaged by the Notch inhibitor drug being used in these patients," said Maillard. The research that included scientists from the University of Pennsylvania, the Swiss Institute for Experimental Cancer Research and the Harvard Medical School appears in the journal Cell Stem Cell. Stem cells created from normal skin cells STANFORD, Calif., -- U.S. scientists say they have devel- oped a technique that turns normal skin cells into rare cancer stem cells. The Stanford University Medical Center researchers said cancer stem cells are thought to be the ones that drive a cancer, and are therefore the targets of any cancer therapy that must kill them in order to be effec- tive. Understanding these cells has been a challenge, how- ever, because they are rare, difficult to isolate and don't grow well in the lab, said Dr. Howard Chang, an assistant professor and senior author of the study. "The upshot is that there may be a way to directly create cancer stem cells in the lab so you don't always have to purify these rare cells from patients in order to study them directly," said Chang. He said the study also demonstrated that cancer stem cells are much more similar to the stem cells found in emb- ryos, which can develop to form all tissue types, than they are to the more-restricted adult stem cells. That finding, said Chang, has important implications for understanding how cells go awry when they become cancerous. The research app- ears in the journal Cell Stem Cell. ------------------------------------------------------------ Potential diabetes drug target identified TORONTO, -- Canadian scientists said they have discovered a novel signaling pathway between the gut, brain and liver that lowers blood sugar when it is activated. The scientists at the Toronto General Hospital Research Institute, led by Dr. Tony Lam, used a rat model to discover that fats can activate a subset of nerves in the intestine, which then send a signal to the brain and subsequently to the liver to lower glucose production. "This is a new approach in devel- oping more effective methods to lower glucose or blood sugar levels in those who are obese or have diabetes," said Lam. "We already knew that the brain and liver can regulate blood glucose levels, but the question has been, how do you thera- peutically target either of these two organs without incurr- ing side effects? "We may have found a way around this prob- lem by suggesting that the gut can be the initial target instead," he added. "If new medicines can be developed that stimulate this sensing mechanism in the gut, we may have an effective way of slowing down the body's production of sugar �?"said Lam. The research appears in the online issue of the journal Science in advance of print publication. Minimally invasive surgery reduces risks SAN FRANCISCO, -- U.S. medical scientists say a new study shows laparoscopic surgery reduces the risk of nosocomial infections by 52 percent when compared with open surgery. Ethicon End-Surgery Inc., a Johnson & Johnson company, con- ducted a retrospective study of more than 11,000 patients undergoing one of three surgical procedures: hysterectomy, cholecystectomy (gallbladder removal) and appendectomy. The researchers said they found laparoscopic surgery was associ- ated with reduction of the risk of nosocomial (hospital acquired) infections during gallbladder removal by 66 per- cent, and during hysterectomy by 52 percent compared with open surgery. The study showed the reduction rates of noso- comial infections during laparoscopic appendectomy were not statistically significant. "This study gives more definitive evidence that laparoscopic surgery reduces the risk of noso- comial infection compared to open surgery, which may lead to improved patient care and potential reductions in costs to the healthcare system, " said Dr. Andrew Brill, director of minimally invasive gynecology at the California Pacific Med- ical Center in San Francisco, one of the lead investigators of the study. The research appears in the journal Surgical Endoscopy. ------------------------------------------------------------ ------------------------------------------------------------ Drug might become new leukemia treatment SAN DIEGO, -- U.S. medical scientists have produced a drug to treat a rare class of blood diseases called myeloprolife- rative disorders, including leukemia. Collaborative discov- eries by stem cell researchers from the University of Cali- fornia-San Diego, the Dana-Farber Cancer Institute, the Mayo Clinic and a San Diego pharmaceutical company, TargeGen, moved the drug into clinical trials. A study led by Dr. Cat- riona Jamieson, an assistant professor of medicine at the UCSD, found an inhibitor that can stop the over-prolifera- tion of blood cells that result in problems with blood clot- ting, heart attacks and, in some cases, leukemia. "As a clinician, I asked myself who is going to get this disease, and what can we do to stop its progression, instead of wait- ing until it evolves into a deadly cancer?" said Jamieson. "This project has been so extraordinary, because a small pharmaceutical company took a big chance on a rare disease." The drug is currently being tested in human clinical trials at the UCSD's School of Medicine, the Mayo Clinic, the M.D. Anderson Cancer Center, the University of Michigan and at Stanford and Harvard Universities. The research is reported in the journal Cancer Cell.
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"If new medicines can be developed that stimulate this sensing mechanism in the gut, we may have an effective way of slowing down the body's production of sugar �?"said Lam. The research appears in the online issue of the journal Science in advance of print publication.
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