Diabetes, Gallstones & Magnesium
A new study shows that a person may entirely avoid the brutal pain of a gallstone attack and the surgery if the magnesium intake is sufficiently high.
Type 2 Diabetes & Gallstones
Magnesium has a type 2 diabetes connection, which in turn has a gallstone connection.
The Karolinska Institute in Sweden undertook a meta-analysis of seven large magnesium/diabetes studies in 2007. Six of the studies found a significant link between high magnesium intake and reduced risk of type 2 diabetes. And the sources of magnesium (either from diet or supplements combined with diet) were equally effective.
The Karolinska team found that diabetes risk dropped by 15 percent for every 100 mg increase in magnesium intake.
Unfortunately, magnesium deficiency can develop fairly easily. Menstruation, prolonged stress, a high intake of starches, alcohol, diuretics and some prescription drugs (such as antibiotics) have all been shown to reduce magnesium levels.
In the February 2008 issue of The American Journal of Gastroenterology, researchers at the University of Kentucky Medical Center note that low magnesium levels have been associated with high insulin concentrations. They write: "Chronic hypersecretion of insulin, a feature of insulin resistance, may increase the cholesterol saturation index in the bile, and thus may facilitate gallstone formation."
Magnesium deficiency may also increase gallstone risk by raising triglyceride levels while lowering HDL cholesterol levels.
Risk Assessment for Gallstones
To investigate the effect of long-term magnesium intake on the risk of gallstone disease, the Kentucky team (in collaboration with Harvard Medical School, Brigham and Women’s Hospital, and the National Cancer Institute) launched a study to follow magnesium intake and medical records for more than 42,000 men.
RESULTS:
2,195 cases of gallstones were diagnosed over an average follow up period of 13 years
The average magnesium intake was about 353 mg per day
The highest magnesium intake was 454 mg per day
The lowest magnesium intake was 262 mg per day
Men with the highest intake were nearly 30 percent less likely to develop gallstones compared to men with the lowest intake
Men with the highest intake from dietary sources alone were 32 percent less likely to develop gallstones
So…chalk it up �?we have a new benefit to add to this already impressive list of health advantages linked to generous magnesium intake:
Reduced risk of cognitive decline
Promotion of strong bones in postmenopausal women
Maintenance of tooth enamel
Heart health support
Management of C-reactive protein (a key marker of inflammation)
Studies have shown that the average adult doesn’t get the RDA of magnesium, which is 420 mg for men and 320 mg for women. Dr.A.Spreen, M.D., recommends 500 mg of magnesium per day, with the added note that magnesium gluconate and chelated magnesium are the preferred supplement forms. Talk to your doctor before adding a magnesium supplement to your daily regimen.
Dietary sources of magnesium include leafy green vegetables, avocados, nuts, and whole grains.
Sources:
"Long-Term Effect of Magnesium Consumption on the Risk of Symptomatic Gallstone Disease Among Men" The American Journal of Gastroenterology, Vol. 103, No. 2, February 2008, amjgastro.com
"Magnesium Linked to Fewer Gallstones" Stephen Daniells, NutraIngredients-USA, 2/26/08, nutraingredients-usa.com