Hi Dee,,,, sometimes good to put your  question in two spots,,,,,, There are kind of two lines of thoughts on how long Lantus lasts(refrigerated, of course) the little flyer in my box says 28 days,,,,, now I only use 15 units so I never empty a bottle by that amount of time,,,,,,, I've heard others say they can use the whole bottle and  their levels don't increase,,,,,,, I have found for myself that it seems to last about 30 days and then my numbers will start creeping up,,,,, so I change mine out once a month!   I take REg/Nph and I use them until their expiration date which is on the box/bottle,,,,, I assume it would be the same for Humalog. I keep all my insulins in the frig/on the door to help them from getting too cold,,,,, never let them freeze and keep them out of sunlight!!!  That's about all I can offer,,,,,, Have a nice day,,,, and Keep smiling, Cuddles/Kathy

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