Experts explain the dangers of mixing drugs, not checking labels, and other common drug mistakes.
By Kathleen Doheny WebMD Feature Reviewed by Louise Chang, MD The football player Terrell Owens blamed his recent trip to the hospital on a bad mix of painkillers and a supplement. The son of Anna Nicole Smith reportedly died with a mixture of the antidepressants Lexapro and Zoloft and the drug methadone in his system. The veracity of these incidents is yet to be determined. But the danger of mixing drugs, supplements, and/or alcohol is very real. At least 1.5 million people in the U.S. are harmed annually by medication errors, according to a report issued in July 2006 by the Institute of Medicine. Reducing your risk, experts agree, is often a matter of using common sense and asking your doctor or pharmacist the right questions. WebMD asked a pharmacist, two doctors, and a nurse to weigh in on the most common mistakes that lead to medication errors and to suggest practical ways to minimize or eliminate the risks. 1. Mixing Drugs That Interact Adversely "Antidepressants and methadone together can be a real problem," says Russell Jenkins, MD, a member of the board of directors for the Institute for Safe Medication Practices in Huntingdon Valley, Pa., and a former primary care doctor for 27 years. "Each drug can increase the sedative effect of the other." "Painkillers and supplements can be a problem, because you don't know what is in the supplements, since they are not under [the same] Food and Drug Administration regulation [as drugs are]," he adds. Certain other combinations -- even if one of the drugs is over-the-counter -- should also be avoided. Many antibiotics reduce the effectiveness of oral contraceptives, says Matthew Grissinger, RPh, a pharmacist and education safety analyst at the Institute for Safe Medication Practices. "Use backup protection if you are on the pill and need an antibiotic." The blood thinner Coumadin, taken by people with blood clots or with heart valve conditions, shouldn't be mixed with ginseng, says Jenkins. Nor should it be used with aspirin, says Grissinger. "It's an additive effect," he says of the Coumadin-aspirin combination. "It increases your chance of internal bleeding or, if you get a cut on your finger, the blood won't clot as quickly." Indeed, there are many drugs and supplements that are off-limits when you are taking Coumadin. If you have elevated blood pressure, even if you're on medication to control the pressure, you should not take over-the-counter oral nasal decongestants without talking first to your pharmacist or doctor, Grissinger says. The preparations can raise your pressure. 2. Mixing Drugs and Alcohol "Prescription pain medicines and antianxiety medications such as Valium and Xanax can have an additive effect when mixed with alcohol," says Grissinger. "You won't be alert. Your driving response time will suffer. Don't mix these together." Another drug that shouldn't be mixed with alcohol: acetaminophen (Tylenol) and alcohol, because it can harm your liver. Cough and cold preparations with antihistamines shouldn't be mixed with alcohol because they will amplify the sedative effects, Grissinger says. This warning applies to the use of narcotic pain medications, too. "Be careful mixing alcohol with certain antibiotics," says Jenkins. "The main antibiotic-alcohol interactions are with metronidazole (Flagyl) and the sulfa drugs -- commonly used antibiotics." An example of a sulfa drug is Bactrim. Mixing metronidazole and alcohol can cause nausea, vomiting, flushing, headache and stomach pain, Jenkins says. 3. Leaving the Doctor's Office Without Enough Information "When you leave your doctor's office, you need to know the name of the medication and what it is for," says Grissinger. Ask how many times a day you should take it, he adds, and how you might react. "Ask for written instructions," says Jenkins. "At the doctor's office, people only remember about a third of what the doctors tells them," he says, citing several studies. 4. The Wrong Prescription From the Pharmacy This isn't always your fault, of course, but there's plenty you can do to reduce the risk. First, how it happens: "A pharmacist may not be able to read the doctor's handwriting," Grissinger says. To remedy this, ask your doctor to write down on the prescription pad what the drug is for. That way, if the drug is one of many with sound-alike, look-alike names, your pharmacist can double-check that he's giving you the right drug by looking at the drug's purpose. Always check your medications before leaving the pharmacy to be sure it's your name on the bottles, Grissinger says. "If you are picking up a refill, open the bottle in front of the pharmacist and make sure the pills look the same. If they don't, ask why not." It might be as simple as the health plan changed manufacturers, he says, but check to be sure. |