Approved Medications to Treat HIV Infection HIV and Its Treatment �? Approved Anti-HIV Medications Generic Name Brand & Other Names Manufacturer FDA Approval Date Class Anti-HIV (also called antiretroviral) medications are used to control the reproduction of the virus and to slow the progression of HIV-related disease. Highly Active Antiretroviral Therapy (HAART) is the recommended treatment for HIV infection. HAART combines three or more anti-HIV medications in a daily regimen. Anti-HIV medications do not cure HIV infection, and individuals taking these medications can still transmit HIV to others. Anti-HIV medications approved by the U.S. Food and Drug Administration (FDA) fall into four classes: 1. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) NRTIs are faulty versions of building blocks that HIV needs to make more copies of itself. When HIV uses an NRTI instead of a normal building block, reproduction of the virus is stalled. 2. Nucleoside Reverse Transcriptase Inhibitors (NRTIs) NNRTIs bind to and disable reverse transcriptase, a protein that HIV needs to make more copies of itself. This information is based on the U.S. Food and Drug Administration's Drugs Used in the Treatment of HIV Infection (available at: http://www.fda.gov/oashi/aids/virals.html). Delavirdine Efavirenz Nevirapine Rescriptor, DLV Sustiva, EFV Viramune, NVP Pfizer Bristol-Myers Squibb Boehringer Ingelheim April 4, 1997 Sept. 17, 1998 June 21, 1996 Abacavir Ziagen, ABC GlaxoSmithKline Dec. 17, 1998 Abacavir, Epzicom GlaxoSmithKline Aug. 2, 2004 Lamivudine Abacavir, Trizivir GlaxoSmithKline Nov. 14, 2000 Lamivudine, Zidovudine Didanosine Videx, ddI, Videx EC Bristol-Myers Squibb Oct. 9, 1991 Oct. 31, 2000 (EC) Emtricitabine Emtriva, FTC, Coviracil Gilead Sciences July 2, 2003 Emtricitabine, Truvada Gilead Sciences Aug. 2, 2004 Tenofovir DF Lamivudine Epivir, 3TC GlaxoSmithKline Nov. 17, 1995 Lamivudine, Combivir GlaxoSmithKline Sept. 27, 1997 Zidovudine Stavudine Zerit, d4T Bristol-Myers Squibb June 24, 1994 Tenofovir DF Viread, TDF Gilead Sciences Oct. 26, 2001 Zalcitabine Hivid, ddC Hoffmann-La Roche June 19, 1992 Zidovudine Retrovir, AZT, ZDV GlaxoSmithKline March 19, 1987 Page 1 of 2 Reviewed Sept. 2005 A Service of the U.S. Department of Health and Human Services Approved Medications to Treat HIV Infection HIV and Its Treatment �? Approved Anti-HIV Medications 3. Protease Inhibitors (PIs) Fusion inhibitors work by blocking HIV entry into cells. 4. Fusion Inhibitors PIs disable protease, a protein that HIV needs to make more copies of itself. This information is based on the U.S. Food and Drug Administration's Drugs Used in the Treatment of HIV Infection (available at: http://www.fda.gov/oashi/aids/virals.html). Amprenavir Agenerase, APV GlaxoSmithKline, Vertex April 15, 1999 Pharmaceuticals Atazanavir Reyataz, ATV Bristol-Myers Squibb June 20, 2003 Fosamprenavir Lexiva, FPV GlaxoSmithKline, Vertex Oct. 20, 2003 Pharmaceuticals Indinavir Crixivan, IDV Merck March 13, 1996 Lopinavir, Kaletra, LPV/r Abbott Laboratories Sept. 15, 2000 Ritonavir Nelfinavir Viracept, NFV Agouron March 14, 1997 Pharmaceuticals Ritonavir Norvir, RTV Abbott Laboratories March 1, 1996 Saquinavir Invirase, SQV Hoffmann-La Roche Nov. 7, 1997 Dec. 6, 1995 Tipranavir Aptivus, TPV Boehringer Ingelheim June 22, 2005 Enfuvirtide Fuzeon, T-20 Hoffmann-La Roche, March 13, 2003 Trimeris Generic Name Brand & Other Names Manufacturer FDA Approval Date Class Page 2 of 2 Reviewed Sept. 2005 A Service of the U.S. Department of Health and Human Services Source: http://aidsinfo.nih.gov/ContentFiles/ApprovedMedstoTreatHIV_FS_en.pdf |
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