I was given Zyban (BUPROPION), along with the patch to help me quit smoking. Bupropion is really an anti-depressent, one of the side effects was that peole no longer wanted to smoke like they used to. It's also being used today to treat cocaine addiction.

 

See link below:

http://www.asam.org/jol/Articles/JAD%2021(2)%20Article1.pdf
 
http://www.google.ca/search?q=cache:AejrI0RQFtoJ:ncadi.samhsa.gov/govpubs/bkd157/10i.aspx+BUPROPION+and+methadone&hl=en&ie=UTF-8
 
My doctor said it may affect the way my methadone worked, she had me come in 2 weeks after to check if my dosage was still holding me okay. Unfortuately it's still pending as I haven't started either one  yet..still working on the head space I need to stop smoking. Has anyone else had any experiences with this?

 Here is a link to a pilot study on Methadone and Bupropion:
http://www.clinicaltrials.gov/ct/show/NCT00060814?order=16