E - Ecstasy (Methylenedioxymethamphetamine; MDMA)
E-bombs - MDMA (methylenedioxymethamphetamine)
E-puddle - Sleeping due to MDMA use/exhaustion
E-tard - Person under the influence of MDMA
Earth - Marijuana cigarette
Easing powder - Opium
Eastside player - Crack Cocaine
Easy lay - Gamma hydroxybutyrate (GHB)
Easy score - Obtaining drugs without difficulties
Eating - Taking a drug orally
Ecstasy - Methylenedioxymethamphetamine (MDMA)
Egg - Crack Cocaine
Egyptians - Methylenedioxymethamphetamine (MDMA)
Eight ball - 1/8 ounce of drugs
Eightball - Crack mixed with heroin
Eighth - Heroin
El diablito (Spanish) - Cocaine, marijuana, heroin and PCP
El diablo (Spanish) - Cocaine, marijuana and heroin
Electric Kool Aid - LSD
Elephant - Marijuana; PCP
Elephant flipping - Use of PCP and MDMA
Elephant trank - PCP
Elephant tranquilizer - PCP
Elvis - LSD
Embalming fluid - PCP
Emergency gun - Instrument used to inject other than a syringe
Emsel - Morphine
Endo - Marijuana
Energizer - PCP
Enoltestovis - Injectable steroids
Ephedrone - Methcathinone
Equipose - Veterinary steroids
Esnortiar (Spanish) - Cocaine
Esra - Marijuana
Essence - Methylenedioxymethamphetamine (MDMA)
Estuffa - Heroin
ET - Alpha-ethyltryptamine
Eve - Methylenedioxymethamphetamine (MDMA)
Everclear - Cocaine; gamma hydroxybutyrate (GHB)
Exiticity - Methylenedioxymethamphetamine (MDMA)
Explorers club - Group of LSD users
Eye opener - Crack; amphetamine
Eye openers - Amphetamine