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| | | From: Johann (Original Message) | Sent: 7/15/2007 8:27 PM |
Hans,
what do you make of this:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1153232
Can you break it down for me? |
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"...the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane..."
This, you probably realize, is a really "bad thing." However, they are playing around with cells and molecules in dishes or tubes. What, exactly, happens in the context of a common diet? That is the important question. There is more than enough evidence to suggest that a common diet that is rich in linoleic acid is really unhealthy. What I find especially significant is the research that shows how cooked meat and a diet rich in linoleic acid is an incredibly unhealthy combination. Read the essay I wrote about saturated fat being the solution, not the problem, for more about this. |
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| The linoleic acid (omega-6) inhibits cellular functions because it's oxidative products shortcircuit the cellular energy (ATP) production machinery. This is termed mitochondrial uncoupling and is a protection mechanism against lipid peroxides which are generated from PUFAs and O2 radicals. The O2 radicals are byproducts of ATP synthesis and shutting down this synthesis prevents them. The energy is then converted directly to heat. Omega-3s uncouple mitochondria even more. I have experienced this while supplementing with them, my body was hot all the time sweating a lot and having low energy. This was exacerbated by trying to exercise - being powerless while sweating like mad ... Birds have relatively highly saturated mitochondrial membranes and can thus use more energy for muscle work during flight rather then heat. Using more energy for heat instead of ATP (in evolutionary terms, not by eating more PUFAs) is also an adaptation to cold climates and correlates with longevity because less O2 radicals are produced. Either less O2 radicals or less PUFAs in the membranes minimize the cellular damage occuring with aging ... |
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