A simplified way of thinking about this is: we are being told that even if the symptoms are exactly like "AIDS," people cannot have it if they are "HIV negative," and yet there is nothing exact about "AIDS." It is based on observations, and it has changed over the years, now including things like cervical cancer, even though few attempts are being made to understand how this can be the case at the molecular and cellular levels. There is also nothing exact about "HIV," as only markers are involved in the tests, and these markers are not unique to "retroviruses," let alone a specific one. At this point, after more than a quarter of a century of research, one can only regard "HIV/AIDS" claims as a kind of "fool's gold" that does not even have the appearance of real gold.
How could this "AIDS" situation be resolved in the most sensible way? By "going back to basics," that is, first, attempt to delineate clinical syndromes based upon observations and markers that are shared, doing so without any preconceptions. Once this is accomplished, researchers could investigate what the patients who are afflicted by these syndromes have in common, such as a great deal of antibiotic usage. It would also be important to follow such people around without their knowledge, because they may be doing illegal things, such as taking certain drugs, that they don't want to mention to their doctors. If this is kind of investigation is not legal, there is a loss of controls and it will be impossible to advance beyond the CS, though if enough people are afflicted, it's likely that at least some will be honest and the problem will be more comprehensible.
If the stressor that is the root cause can be determined, then it is not just a scientific issue any longer, that is, the government may decide that it will not devote resources to those who knowingly harm themselves. If this is not done, various "therapies" and "treatments" can be tried, but I'm not especially interested in this sort of endeavor because there is so much conflict of interest involved and because things become so complicated so quickly that attempting to use the scientific method is impossible.