Most people know what "keloids" are - scarring that often occurs at the site of surgical incisions. One study found "enhanced arachidonic acid (AA) levels, were prevalent in keloid formations..." ( Prostaglandins Leukot Essent Fatty Acids. 2000 Nov;63(5):255-62.), while the author of another study wrote that "Keloid formation has been linked to aberrant fibroblast activity, exacerbated by growth factors and inflammatory mediators..." (Wound Repair Regen. 2007 Jan-Feb;15(1):122-33.).
A new study on wound healing suggests that it is a process that is "fine tuned:"
QUOTE: Once the growth factor is available, the fibroblast expresses the contractile proteins, sticks more firmly to the matrix and starts to contract, pulling the matrix tightly together. In the process it liberates yet more growth factor that in turn stimulates other fibroblasts to become contractile. The mechanical nature of the switch ensures that the contraction only develops when the matrix is "ready."
Although this process will heal a wound quickly, if left unchecked, it can also lead to a buildup of fibrous tissue. Following trauma to vital organs such as the heart, lung, liver and kidney, overzealous fibroblasts can continue to build fibrous strands, leading to scar tissue buildup that can impair the organ's function. This condition, called "fibrosis", can be fatal. Fibroblasts are also the culprits in problems caused by implants -- if the implant is too smooth, it never becomes properly incorporated into the connective tissue... UNQUOTE.
Source: http://www.sciencedaily.com/releases/2007/12/071217092914.htm
It is not just my idea that having arachidonic acid in your cells is potentially much more dangerous than the irritation or unsightliness of keloids, for example:
QUOTE: Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase enzymes to biologically active products, including PGs, leukotrienes, epoxyeicosatrienoic acids, and hydroxyeicosatetraenoic acids. Some of these products have profibrotic properties and may represent a pathway by which inflammatory cells initiate and mediate the development of cardiac fibrosis... UNQUOTE.
Source: The Journal of Immunology, 2007, 178: 641-646.
I have told people to think about what would happen if they used rocket fuel for their car engines. A tiny amount wouldn't do damage, but a lot would. Having AA in your cells means that what could have been easy to "cure" might become life threatening, and there is no benefit to weigh against getting AA out and replacing it with the natural Mead acid (so far as I can tell, both in my personal experience and my examination of the relevant evidence).
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