Another important passage from that study I cited in the post above is:
"The 5'-NCR of the HCV-RNA acts, through an IRES, as the starting area for translation. However, the respective sequence sections present in the DNA may serve as a potential source of transcriptional activity. This can be explained in terms of ongoing DNA rearrangements(19,20) and the exchangeability of IRES units(21) that result in chimeric transcripts. Our data would further indicate that the sequence stretches of up to 272 base pairs detected by PCR could be present in some kind of extra-chromosomal 'rearranged DNA' (belonging to mobile DNA elements like DNA transposons). This interpretation is supported by a report on expressed-sequence tag (EST) libraries.(22) It demonstrates that a human RNA library already contains a sequence stretch (286 nucleotides with 92.7% homology) of the HCV genome that is not contained as such in human DNA libraries." |
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