| It is testing of different things with a transgenic mouse deficient in a gene not related to fat metabolism. Since it has no phenotype normally we are trying to find some treatment which would make a difference between the normal controls and the transgenic. Of course different 1 month short tests of toxic chemicals would be included but I proposed to do a longer term test with the influence of diet on the mice. As a control, normal mice can be fed the normal versus SFA diet or PUFA rich diet. It can last 2-3 years if I can writeup an acceptable detailed proposal ... |
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