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I think that I have read something interesting in this article : http://www.liversupport.com/wordpress/2008/03/sulfasalazine%e2%80%99s-potential-for-reversing-fibrosi/
QUOTE :
The Signals Responsible
A well-known protein that controls the activity of over 200 genes, nuclear factor-kappa B (NF-κB) emerged as the agent responsible for instructing cells to resist death. Mann explained that the activation of hepatic stellate cells into myofibroblasts was accompanied by an increase in their NF-κB activity. The presence of this protein is believed to be the primary reason why hepatic stellate cells are able to resist death, their demise of which could allow liver tissue to heal. The NF-κB activity is a key player in how much scarring a liver incurs. As hepatic stellate cells resist death, scar formation persists and the liver progresses towards cirrhosis.
UNQUOTE
And they say also that sulfasalazine could be very useful against cirrhosis.
And I have read that sulfasalazine inhibits the arachidonic acid metabolizing enzymes.
See for instance here : http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20S)/SALAZOPYRIN.html
QUOTE :
On the lipoxygenase side of the arachidonic acid cascade, sulfasalazine has been shown to exert an inhibitory activity on several enzymes including 5-LO and LTC4 synthetase. In line with this effect sulfasalazine has been shown to inhibit the release of lipoxygenase product from inflammatory cells and tissue.
Taken together, these effects of sulfasalazine on arachidonic acid metabolizing enzymes would lead to a decrease in pro-inflammatory lipoxygenase products with a simultaneous increase in immunosuppressive, anti-inflammatory prostaglandins, which may have a bearing on the clinical activity.
UNQUOTE
Therefore I think more and more that if we haven't arachidonic acid in the cells, it would be possible to cure hepatitis, for instance hepatitis C.
Any thought ? |
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