We are again at the lipoxygenase (5-LOX) here. 5-LOX and its metabolite LTB4 look the worst of all AA stuff - I haven't seen any citation yet showing its benefits. Pretty much responsible for cancer metastasis and allergies (the LTC series). On the other hand there are some "benefits" of the COX-1,2 (cyclooxygenase) class AA metabolites such as for reproduction, stem cell, immune tolerance and muscle growth. That's why the selective 5-LOX inhibitors such as AKBA have so positive effects and COX inhibitors such as aspirin/NSAIDS always come with side negative effects. The most interesting thing is that the best natural 5-LOX inhibitor is Mead acid ... |