And here are some follow-up posts of mine:
More evidence to the point I've made in my posts above:
Diabetes 54:3103-3111, 2005
Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the
Risk of Future 10-Year Progression of Diabetic Retinopathy and
Nephropathy in the Diabetes Control and Complications Trial and
Epidemiology of Diabetes Interventions and Complications Participants
With Type 1 Diabetes
Saul Genuth1, Wanjie Sun2, Patricia Cleary2, David R. Sell3, William
Dahms4, John Malone5, William Sivitz6, Vincent M. Monnier3,7, and for
the DCCT Skin Collagen Ancillary Study Group*
"...Although CML is in part a downstream product of furosine, thus
arising from hyperglycemia, CML is also a product of lipid peroxidation
and glycoxidation (30) and of metal and peroxynitrite catalyzed
oxidative stress (31); overproduction of reactive oxygen species in
mitochondria exposed to excessive cellular flux of glucose contributes
to CML formation..."
Online at:
http://diabetes.diabetesjournals.org/cgi/content/full/54/11/3103
Mainly, I have pointed out how experimental findings have been
misinterpreted. I present many of my conclusions at:
http://groups.msn.com/TheScientificDebateForum-
People like yourself, however, will not address obvious refutations,
which are the basis for "getting science right." For example, if rats
are fed a fat free diet, and live well and long, how can the claim of
"essential fatty acids" continue? And as I pointed out, this direct,
on point experiment was conducted in 1948 ! Yet people like MattLB do
not seem to understand that human reason and basic logic underly the
scientific method. People like him/her, instead, argue, implicitly or
explicity, that the textbook dogma must be correct, even though the
textbooks are filled with qualified statements. When on objectively
investigates the experiments upon which these claims are based, one
finds that they are hardly what one expects. I pointed this out to
him/her in may contexts, for example, I researched the literature on
"membranes," and the scientists make clear that their ideas are based
upon assumptions. One scientist who has conducted on point experiments
in this field is Gilbert Ling, who has also done excellent reviews of
the relevant literature. MattLB dismisses Ling's endeavors with a wave
of the proverbial hand.
Moreover, when asked, MattLB never cites, nor provides, a formal
hypothesis for any of his claims, something required of the scientific
method. I, on the other hand, have challenged him and others to do on
point experiments: the person who is wrong must pay for all expenses.
He has never shown any interest in such proposals. If MattLB thinks he
is so "scientific," why does he run from doing the actual experiments
that would determine who is correct? MattLB, please explain to the
readers why you speak loudly and carry such a small, fragile stick.
With regard to "essential fatty acids," "lipid bilayer membranes,"
"trans fat," and this "glycation" issue, the experiments would be
simple to do. One uses lab animals that have often been used in this
context in the past and one provides them with different diets to see
if there is a major difference. With glycation, if one claims that too
much sugar is the problem (or sugar in the presence of high protein
foods), then there is no problem doing the proper experients. However,
one must be willing to do the experiments so that the alternative ideas
are respresented. In this case, I would have a group of animals fed
the meat and sugar diet, but it would be prepared the way I would want
it to be. Then, another group would be fed this diet, but it would be
prepared differently, with the meat being fried in a highly unsaturated
oil. If the latter group was much less healthy and died at younger
ages, it would be clear that the lipid peroxidation was the problem,
not the sugar and protein food. Obviously, one could try several
different variations, but if one does not control for possibily
relevant factors, one is violating the scientific method. For some
reason, this simple point is unable to penetrate the mind of MattLB.
|
Free Forum Hosting
Important Announcement
Prev Message
