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Bruce, you posted a link to study showing that there were no ill effects of meat & animal fat only diet for 1 year. I also saw another study of mainly beef & no grain+milk diet for cup of months with positive effect on total cholesterol and allergies. I guess there is a threshold for the dietary HCAs which is not reached if the meat is not burned. HCAs are mutagenic like VitC or green tea catechin if dosed "properly" and combined with things like free iron, PUFAs etc. Sometimes this can stimulate the body defense mechanisms at lower doses.
Now what are the molecular mechanisms behind the deleterious effects of carbs? I agree with Hans that we should make this clear first. I know e.g. that fructose is not metabolized optimally and is stealing phosphorus from ATP. It is also significantly more prone to form AGEs but is normally cleared from the blood stream by liver so the resulting triglycerides may represent a bigger problem if taken in excess. Also the adipocytes may become overloaded with fat resulting from excessive carbs and trigger systemic inflammation but this all happen only when consumed in EXCESS in relation to current needs according to the level of physical activity. Another thing which would deserve closer investigation is that carbohydrates inhibit delta-5-desaturase which is an enzyme required for the synthesis of Mead acid. They also seem to stimulate sex steroid hormones which do the same to desaturases. Some studies suggest that the lack of PUFAs used for controlling the immune response and cell signaling (the "experts" are only aware of AA but the same can be applied to Mead acid) is responsible for diseases like diabetes or atopy. Also insulin accelerates aging but only if elevated continuously - Hans' diet gives just 3 insulin spikes a day what is probably beneficial for tissue rebuilding especially when combined with dietary protein. |
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