I think the relevant passages are quoted on the fish oil and EFA thread, but they did it on rats anyway. The person making the claim has to supply the evidence - I was pointing out that even with rats the "EFA" claim was refuted (and rats seem to be more adapted to these molecules than people, based upon threshold levels for mammary cancers). However, the molecular-level evidence does show that without AA in your cells, your body won't generate the inflammatory molecules that cause all kinds of problems. LTB4 is one example. With Mead acid in your cells, you can only generate up to LTA3 in more than trace amounts. Nobody has proved the presence of any fatty acid in their bodies, with the exception of a small number of studies one can find on pubmed.com. However, I have experienced several effects which are consistent with having the different PUFAs in one's cells (chronic inflammatory problems with AA, improper wound healing with too much omega 3s, and very temporary inflammation with Mead acid).
I have been doing my own experiments (on myself), and I have to admit that I feel a bit more confident with this knowing that my great grandparents lived to be 96 and 100 on a similar diet. Again, it's all about the specifics. Someone who eats my diet, but eats every hour and a half, might indeed cause themselves insulin resistance issues at some point, for example. There is much that still needs to be learned, and that is obvious if you read sciencedaily.com each day, as I do. The "trick" is to be able to integrate the existing body of evidence comprehensively. When I began my nutritional research, I was open to everything, and I had no idea where it would lead. I couldn't imagine myself ever eating "junk food," rich in SFAs, as I do now, but that is where the evidence led me. From what I can tell, you don't seem to be able to do this, nor do you seem to understand the molecular-level evidence very well.
For instance, when you talk about the "markers" being in the "optimal" range, you fail to realize that this is based upon epidemiology, but then you criticize epidemiology (even though most of the studies I cited with regard to cooked meat had to do with HCAs, and so are molecular-level). I've told people in the past that if they "normalize" their biochemistry (getting the AA out is one thing that must be done), then they will be able to "cure" themselves. For example, I needed to take stomach acid supplements in large amounts a couple of years ago, but I no longer take any. How did I determine when to take less, then when to take none? I listened to my body. I often try new things, to see how my body responds. I do realize that unless one experiences what I have, it's difficult to believe that one can eat some "junk food," plenty of sugar and salt, etc. I wouldn't have believed myself (if someone told me these things 10 years ago, for example). |
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