Here's a study that found that LDL and HDL inhibit AA metabolization, which is likely at least one factor in the findings that lowering cholesterol leads to higher cancer risk:
QUOTE: ...plasma from hypercholesterolaemic and control rabbits, when added to the incubation mixture, significantly inhibited platelet aggregation and eicosanoid production. 3. High- and low-density lipoprotein (HDL and LDL, respectively) concentrations increased several-fold in plasma with cholesterol feeding. When added directly to the incubation mixture, both HDL and LDL inhibited platelet aggregation, as well as AA metabolism. 4. Haptoglobin, albumin and Cohn's fraction IV, but not globulins, exhibited antiplatelet and anti-AA metabolism activities. Their concentrations in plasma were not affected by cholesterol feeding. 5. We conclude that LDL and HDL account for at least some of the inhibition of AA metabolism produced by plasma. UNQUOTE.
Source: Clin Exp Pharmacol Physiol. 2008 Jan 21 [Epub ahead of print]. |
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