QUOTE: ...Results Changes in gene expression as observed in response to dietary oxidized cholesterol were strongly dependent on the type of fat. In the rats fed coconut oil, the expression of 7 genes (5 up�?and 2 down–regulated) was altered by dietary oxidized cholesterol, while in the rats fed salmon oil, the expression of 50 genes (16 up�?and 34 down–regulated) was altered. 29 genes (22 up- and 7 down–regulated) were identified as possible targets for an altered gene expression by dietary salmon oil as compared to dietary coconut oil.
Conclusion The present study showed that dietary oxidized cholesterol transcriptionally affects many genes involved in xenobiotic metabolism and stress response—an effect that was amplified by the administration of fish oil as dietary fat. UNQUOTE.
Source: European Journal of Nutrition, Volume 44, Number 4 / June, 2005.
On the internet: http://www.springerlink.com/content/7q1da2uxdfbtqagc/ |
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