Although the Preview Pane isn't as big a problem as it used to be a few years back, it is still a possible means for hackers to compromise yours system.
I personally hate turning off HTML so have the preview pane disabled. Reason being is that hackers will always find a way around MS security. Also another reason why I don't use I.E.
On a side note, got an email from a friend a few months back. Because of the Subject line alone, I figured it had to be a virus, so didn't open it. I emailed her to warn her that she may have a virus, and sure enough she did and the email sent was a worm virus. She had been using the preview pane and that was how she got it. She eventually got rid of it, but took her a long time to do it. It wasn't a high risk virus, more of an annoyance than anything else.
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