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Medical Info~Q&A : Drugs That Mess With How Methadone Works
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 Message 1 of 3 in Discussion 
From: MSN Nickname©Sha  (Original Message)Sent: 10/23/2007 4:11 AM
Drugs Which May Lower Plasma Levels of Methadone or Decrease Methadone EffectsGeneric
 
Name Action/Use Brands/Examples

Butabarbital sodium, mephobarbital, phenobarbital, pentobarbital, secobarbital barbiturate sedatives and/or hypnotics Bitosol Sodium, Mebaral, Nembutal, Phenobarbital, Seconal
carbamazepine anticonvulsant for epilepsy and trigeminal neuralgia Atretol, Tegretol
ethanol chronic use wine, beer, whiskey, etc.
phenytoin control of seizures Dilantin
rifampin Treatment of pulmonary tuberculosis Rifadin, Rifamate, Rifater, Rimactane
urinary acidifiers, ascorbic acid keeps calcium soluble, controls urine-induced skin irritations, vitamin C K-Phos, Vitamin C (large doses)
 
Drugs Which May Increase Plasma Levels of Methadone or Increase Methadone EffectsGeneric
 
Name Action/Use Brands/Examples

amitriptyline treatment of depression and anxiety Elavil, Endep, Entrafon, Limbitrol, Triavil
cimetidine H2 receptor antagonist for the treatment of gastric and duodenal ulcers, and gastric reflux disease Tagamet
diazepam control of anxiety and stress Dizac Vairelease, Valium
ethanol acute use wine, beer, whiskey, etc.
fluvoxamine maleate serotonin reuptake inhibitor for treatment of depression and compulsive disorders Luvox
ketoconazole anti-fungal agent Nizoral Tablets
urinary alkalinizers treatment of kidney stones, gout therapy Bicitra, Polycitra
Charts from A.T. Forum, (1997, Spring). Vol. VI, #2, p. 3.
Some drugs that cause false positives
 
 


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 Message 2 of 3 in Discussion 
From: MSN Nickname©ShaSent: 10/23/2007 4:18 AM
I was given Zyban (BUPROPION), along with the patch to help me quit smoking. Bupropion is really an anti-depressent, one of the side effects was that peole no longer wanted to smoke like they used to. It's also being used today to treat cocaine addiction.
 
See link below:

http://www.asam.org/jol/Articles/JAD%2021(2)%20Article1.pdf
 
http://www.google.ca/search?q=cache:AejrI0RQFtoJ:ncadi.samhsa.gov/govpubs/bkd157/10i.aspx+BUPROPION+and+methadone&hl=en&ie=UTF-8
 
My doctor said it may affect the way my methadone worked, she had me come in 2 weeks after to check if my dosage was still holding me okay. Unfortuately it's still pending as I haven't started either one  yet..still working on the head space I need to stop smoking. Has anyone else had any experiences with this?

 Here is a link to a pilot study on Methadone and Bupropion:
http://www.clinicaltrials.gov/ct/show/NCT00060814?order=16

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 Message 3 of 3 in Discussion 
From: MSN NicknameSuziblues2Sent: 10/23/2007 6:34 PM
Thank you for this info. 
 
I remember my sister was on Dilantin for her siezures, and the clinic kept hassleing her because for some reason it would make her urine tests come up dirty.  She was getting so angry because she wasn't using!
They kept making her do monitored urine tests, and they would watch her drink her methadone, and STILL would hassle her because not only would her urine tests come up positive but sometimes they would come up with no methadone!   But WTF, they were WATCHING her piss and WATCHING her drink her methadone!
 
FINALLY she did some research and brought it into the clinic herself, proving that Dilatin will mess with urine tests. 
 
In the defense of the methadone clinic, I should say that this was years ago, maybe about 7 or 8 years ago, so I guess they didn't know about it yet.  But still........they should have known.  It would've saved my sister a lot of grief.
 
But thanx for this very important info.
luv,
sue