Here's interesting information that I have yet to hear in the "mainstream media," despite how many news stories there have been on anthrax since this was published:
Abstract: Anthrax causes profound inflammation and systemic shock. A recent study has shown that anthrax lethal toxin represses the transcriptional activity of the glucocorticoid receptor, which is a crucial component of the body's defenses against inflammation. The study reports evidence that lethal toxin blocks the glucocorticoid receptor by inhibiting the p38 mitogen-activated protein kinase pathway. Thus, these findings suggest that glucocorticoid receptor inactivation contributes to anthrax toxicity and raise the possibility of developing new strategies to combat this deadly disease.
Source: Trends in Pharmacological Sciences;
Volume 24, Issue 11, November 2003, Pages 558-559. |
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