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General : Biochemistry (Overexpression)
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 Message 1 of 3 in Discussion 
From: Jaom  (Original Message)Sent: 8/26/2008 8:24 PM
If anyone is familiar with biochemistry plz help.

I know the advantages and disadvantages with expressing recombinant proteins...but what about Overexpression...

(For what purposes do you Overexpress?)


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Reply
 Message 2 of 3 in Discussion 
From: MSN Nickname·Steve·Sent: 8/26/2008 11:13 PM
I was not familiar with the many applications of overexpression until I tried some keyword searches.  Searching [overexpression introduction] gives many articles.  Here are a few that illustrate beneficial responses to overexpression.

Steve
 

Overexpression of human catalaze in transgenic mice increased life span:
http://student.biology.arizona.edu/honors2005/group07/home07.html

 
TNF- overexpression protects against pulmonary fibrosis by BLM or TGF-ß:
http://ajrcmb.atsjournals.org/cgi/content/full/29/6/669
 
 
Overexpression of human acid ceramidase increases cell survival:
http://www.jem.org/cgi/content/full/192/5/601
 

Wikipedia article on gene expression:
http://en.wikipedia.org/wiki/Gene_expression
 

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 Message 3 of 3 in Discussion 
From: JaomSent: 9/11/2008 11:25 AM
Thx, someone told me that "overexpression" is just "expression" when talkin about recombinant proteins...