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Nutrition : Insulin and Its Metabolic Effects
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 Message 1 of 30 in Discussion 
From: MSN NicknameMakeMyDay8  (Original Message)Sent: 6/28/2006 9:25 AM
Hi Hans
 
You probably have read this article on Mercola.com
 
 
There is another article about sugar on
 
 
Green Tea seems to contain too much fluoride
 
 
In contrast to your statements it is claimed  that sugar is bad. I read both of them and there seem to be plenty of reasons why sugar really seems to be bad. Moreover the sugar intake per person in the US increases constantly so even according to your opinion, that the media claims it to be bad, sugar is used even more often.
I don't drink Green Tea anymore after I read the article about Fluoride. What is your opinion on that?
 
The oldest humans are found in south Okinawa. If I remember correct they don't eat any diary products. That would be contrary to what you say in your diet recommendation.
I'm looking forward to reading your answers.
 
Greets
 
Mankemyday


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Reply
 Message 16 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 7/25/2006 2:56 PM
Hi Hans!
 
I ordered some Beatine HCL two weeks ago and started testing how much I can take. Unfortunatley it's very warm here and I start sweating during every meal and I'm very ill at the moment so I stopped taking it but I definetly can take 1950mg (probably even 2600 mg) without feeling any burning sensation. What amounts are needed to guarantee a proper digestion and how much Betaine HCL did you take to every meal? Has your endogenous stomach acid production normalized since then? I even thought about taking some enzymes (lipases, proteinases, amylase) because when I was in hospital I was diagnosed with some pancreatic insuficiency (amylase was very low). However when I took those enzymes I didn't feel better.
 
Slowly the whole picture of what is going on with me and why starts to form. Kofi answered a post of mine in the Life Extension newsgroup and even he didn't know what blood tests were done and what came out he is completely right in nearly everything he says. I underlined all of his statements that are true and can be backuped by findings.
 
Kofi:
 

Since this is a condition I have, let me toss in my two cents.<o:p></o:p>

If you do have mercury, you're almost certainly low in selenium and high
in lipid peroxide. Mercury also stimulates antibody producing B-cells
(through BLYS, the same B-cell stimulating factor which gets elevated in
lupus). The result is more autoimmunity if you're autoimmune or more
allergies if you're allergic
.<o:p></o:p>

Constant fatigue might indicate damage to your trigeminal nerve which is <o:p></o:p>

keeping you up at nights/preventing deep sleep.<o:p></o:p>

Mercury also knocks out growth hormone (as does homocysteine). You
might want to check your DHEA, cortisol, testosterone, DHT and IGF-I/gh
function
. Most people wait to see if the other supplements bring back gh <o:p></o:p>

function before considering gh shots (they'll knock out endogenous gh
secretion). Without adequate IGF-I/gh signaling, your body's stem cells
can't do their normal repair function. Joints wear down, nerves get
into chronic pain, your brain gets depressed and fatigued.<o:p></o:p>

The nutritional deficiencies will leave you prone to inflammation and
infection and make it difficult to process sugar and other high glycemic
index foods
.
You should also avoid fats which produce too much
arachidonic acid and PGE2. Limit yourself to olive oil, fish oils and
flax seed oil.
No fried or processed foods.<o:p></o:p>

Homocysteine's probably going to be a problem. Hammer it with folic
acid, methyl-B12, choline, TMG, SAMe, creatine and whatever else is
under the kitchen sink.<o:p></o:p>

You probably have a magnesium deficiency (which needs calcium and
phosphorus for best absorption). Magnesium deficiency elevates
substance P (causing pain). Grape seed extract blocks ACE (the
angiotensin converting enzyme). ACE is necessary to break down
substance P and bradykinin. In other words, more grape seed extract =
more substance P.<o:p></o:p>

I take melatonin at bedtime. It's a neural antioxidant that gets
exhausted under a lot of oxidative stress.<o:p></o:p>

 
 

Reply
 Message 17 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 7/26/2006 6:10 PM
He seems to be on the right track, but you have to be so careful about introducing new foods or supplements; otherwise, you won't know what is having the effects you experience. I took a bit over 2 grams of the stomach acid at one meal and had no buring or warm sensations, but now I take much smaller amounts, about half a gram. I'm not sure I understand why you stopped taking them entirely - can you explain?

I don't know what is considered "normal," but it will vary from one person to another, and it can vary even within an individual, depending upon what you are eating, your age, etc. If you tell me what you are doing, eating, etc., in great detail, I will offer you my ideas, but at this point, I don't really understand what your problem is - can you explain the symptoms, your diet, your lifestyle, your previous lifestyle (if it differs from your present one), etc?


Reply
 Message 18 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 7/28/2006 1:18 PM

Sure. <o:p></o:p>

 <o:p></o:p>

I'm 22 now and things started with 12-13 years of age. The first symptoms were a decline in attention/concentration and some atopic eczema which I had for the first time in my life. Probably puberty. With 14 I reached the maximum of dental amalgam fillings in my mouth. I had swollen lymph nodes now and then but although I visited and specialist the reasons for this were unknown. The only thing that doctor found out was that I had an iron deficiency. The iron deficiency is not present anymore and seemed not to have anything to do with my lymph nodes and the other symptoms. I did sports since I was young (tennis, biking, soccer). From age 13-15 I started playing soccer in a small club here. I was skinny but did very good in running and was an average player. We live in the countryside and even had our own garden (in 2000 unfortunately a house was built there) where we had all kinds of vegetables and salad so during summer we didn’t have to buy them. I ate all kinds of food but it was more or less a high carb diet. Fast Food about once a week or less.<o:p></o:p>

With 16 sports only sometimes, school got a little harder, some parties on weekends.<o:p></o:p>

With 17-18 I noticed another symptom, I couldn’t stand alcohol anymore and I got digestion problems. Stool was always pulpy. <o:p></o:p>

I joined an athletic club and trained very hard (up to 5 times a week but normaly 3 times) but when I turned 19 I got more and more exhausted although I trained more and had my breaks. This was when I stopped athletics because many people advised me that I needed a break (I didn’t drink alcohol, didn’t smoke, didn’t take drugs, I had enough sleep).<o:p></o:p>

Things got worse after I did my final examination and had to join the forces for 9 months when I was 19. Light and noise sensitivity started. We did sports on regular bases but my stamina was low all the time and I collapsed. They brought me to hospital. After three weeks of all kinds of tests I was diagnosed with an exocrine pancreatic insufficiency and depression to explain the light and noise sensitivity and my bad concentration. They prescribed me some drugs but with all the side-effects things got even worse.<o:p></o:p>

To sum it up I’m allergic to all kinds of foods especially high glycemic foods and other things. My eyes are swollen nearly every day so is my nose. I lost weight my attention is horrible. Since I avoided high glycemic foods things got a little better but this is no bases to live a life. Fatigue is a big problem for me. <o:p></o:p>

Also interesting are my mental changes. I can’t recover from stress and I’m not able to withdraw myself into me. I often can’t evade my environment. When I try to learn something and someone enters the room I’m not able to do so. It’s like this person doesn’t only enter this room but also my brain. It doesn’t matter which person but she/he takes away my rest of attention. Social interaction got very hard it takes me hours to write small texts. I mostly only try smalltalk because I’m not able to express myself like when I was healthy.  When I watch a sad scene on TV I’m mostly not able to elude myself of it. I try hard not to cry like all the actors. <o:p></o:p>

In my eyes mercury could be responsible for this. As long as my nerves or whatever don’t recover I’m won’t be able to live a normal life like everyone else is doing and I did before.<o:p></o:p>

<o:p> </o:p>

At the moment I mostly eat meat, rice, potatoes (boiled), salad, butter, potato bread, boiled eggs, vegetables, small amounts of cheese. Everything else leads to atopic eczema, strong digestion problems (corn, milk, suger etc.) and strong swollen eyes. Even berries (because of their sugar) are not very optimal for me. These food allergies probably developed because of my low stomach acid but I will see.


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 Message 19 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 7/28/2006 5:25 PM
What you are describing has clear "chronic fatigue syndrome" elements to it, so I'm surprised nobody has mentioned this to you, or have they? In any case, it sounds to me like your body is overloaded with arachidonic acid (AA), and that these various symptoms are just "variations on a theme." It takes about 2 years to get the AA out of your body, and that is if you know how to do it correctly (and safely, of course). I would advise you to stop eating meat unless it is very low in fat and boiled. You can use gelatin, however, to make food - that should be helpful, actually. The AA makes your body much more prone to "inflammatory" problems, and it seems like you have several of them. Keep this in mind: the evidence suggests to me that if you get the AA out of your cells and it is replaced by the natural Mead acid, you will be much more resistant to "inflammatory" problems, except when it is needed, such as when you get a cut. If you don't get the AA out, things like reactive metals will be much more of a problem then they need to be. Did you read the post I did recently, entitled The Myth of Low Iron / Anemia?

At this point, you can try the diet and supplements that "cured" me, or you can try something else, but usually you need to wait at least a few weeks to see results, and that is only if you are very strict about doing everything you are supposed to do and avoiding things that are "off limits." With myself, I noticed some benefits of getting the AA out of my cells quickly, but others took a couple of years, so keep that in mind.

Reply
 Message 20 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 7/31/2006 4:56 PM
Your thread about the myth of Iron/Anemia was very interesting to read. I keep in mind that supplementing it could be the last thing someone wants to do in order to get healthy.
Just in case you read sth. about it I want to describe another small problem. It seems that my concentration gets better when I use Whey Protein + Vitamin C (about 1-2 grams of calcium ascorbate) + Vitamin E (200 IU, gamma-Tocopherol 400mg, delta- and beta-Tocopherol 140mg). However I always get sick about 1-2 hours later when I take those Vitamin E softgels. Do you know of any foods that should not be taken with Vitamin E or any other cause for "Vitamin-E-Sickness"?
By the way do you have a special opinion on water? What kind of water do you drink (mineral, tap, destiled)?
When you go to work what do you do during lunch? Do you bring the food along from home? I think you know how those canteens look like and what kind of food they offer (always pasta, meat, salad etc.) there. What would you go for?
Have a nice day.
 

Reply
 Message 21 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 7/31/2006 5:39 PM
Have you tired the protein without the vitamin C and E?

As to water, I have a counter top filtration unit. The water is forced into it and then it comes out it's own little faucet when you pull out a lever.

If I need to take a meal with me, I usually take a boiled egg, some cheese, buttered French bread, dried fruit, chocolate, shredded coconut that I grind into a powder, and my ricotta concoctions. If you don't have some containers to use and also those cold packs, you can get all that cheaply enough.

You would need to be more specific about what is available to you. I used to eat at the Chinese food buffets that were popular here several years ago. Now I never eat any food tha I don't prepare myself. At those buffets, they had vegetarian sushi, for example, but that is low in protein and may have high concentrations of bacteria that will cause GI inflammation.

Reply
 Message 22 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 7/31/2006 5:46 PM
Oh, also, when you say you "get sick," can you describe what happens in as much detail as possible?

Reply
 Message 23 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 8/1/2006 8:16 PM
Nausea probably is the right word. It starts slowly and feels like when you ate too. It rises for about 30 minutes and then declines for about 30 minutes till I feel normal again.

Reply
 Message 24 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 8/2/2006 7:57 PM
Well, there is obviously a reaction to something you are eating, but again, I need more information to research this for you. The biggest problem I encounter is that people don't provide me with enough information, mostly because they don't realize that things they consider unimportant might be the key to their problems, and in my case the low salt diet appears to have been.

Reply
 Message 25 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 8/3/2006 8:00 AM
Yes, I get your point but without my concentration nothing comes to my mind that is important. I will keep testing however and hopefully find a solution.
Perhaps the dose is too high.

Reply
 Message 26 of 30 in Discussion 
From: MSN NicknameMakeMyDay8Sent: 8/4/2006 8:31 AM
 I now know the cause of my nausea after taking Vitamin E. The cause is Calcium Ascorbate. I took one Vitamin E softgel during dinner (6 p.m.) yesterday and had no problems afterwards. At about 10:15 p.m. I took some Calcium Ascorbate and at about 10:45 p.m. I felt sick again like all the times before when I took Vitamin E (I always took Calcium Ascorbate and Vitamin E at the same time).
Do you have any guess why Calcium Ascorbate and Vitamin E can lead to nausea?

Reply
 Message 27 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 8/4/2006 7:12 PM
Several possibilities: only take supplements like these at the beginning of the meal, perhaps after eating about one tenth of it. Also, don't lie down after eating the meal - wait at least an hour before lying down. And of course it could be some other ingredient, but remember that ascorbate is acidic, and if your gut is sensitive, that could cause the effect, depending upon dosage.

Reply
 Message 28 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/29/2007 6:32 AM
Here's a new study - the researchers are making the same point I did in my original post to this thread:
 
Clin Nutr. 2007 May 14; [Epub ahead of print].
 
"Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults."
 
BACKGROUND & AIMS: Arachidonic acid, a precursor to a series of inflammatory mediators, may contribute to the development of insulin resistance. We examined the association between adipose tissue arachidonic acid and the metabolic syndrome in Costa Rica, a country in which the metabolic syndrome is highly prevalent. METHODS: The 484 study participants each provided a fasting blood sample and an adipose tissue biopsy that was analyzed for fatty acid composition. Criteria for the metabolic syndrome were those established in the Third Report of the National Cholesterol Education Program Expert Panel. The data were analyzed by multivariate logistic regression. RESULTS: Subjects with greater adipose tissue arachidonic acid content had an increasing risk of the metabolic syndrome across quintiles: odds ratio (95% confidence interval), 1.00; 1.51 (0.78-2.91); 2.40 (1.26-4.55); 3.50 (1.84-6.66); and 6.01 (3.11-11.61); test for trend, P<0.0001, after adjustment for age, gender and area of residence. Further adjustment for metabolic risk factors, including adipose fatty acids and body mass index, did not significantly modify the result. Adipose tissue arachidonic acid was also independently associated with abdominal obesity, hypertriglyceridemia, elevated fasting glucose, and high blood pressure. CONCLUSIONS: This study identifies arachidonic acid as an important independent marker of metabolic dysregulation. A better understanding of the role of this fatty acid in the pathogenesis of the metabolic syndrome is warranted.
 

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 Message 29 of 30 in Discussion 
From: MSN Nicknametaka00381Sent: 7/24/2007 3:14 AM
Speaking of CFS there is an exhaustive thread focused on the Th1/Th2 imbalances and latent viruses with many Medline abstracts at:
http://www.mindandmuscle.net/forum/index.php?showtopic=29303

By introducing Mead acid into the cells the Th2 allergy responses are greatly reduced but can it also correct the Th1/Th2 balance, i.e. completely cure allergies? So far I came across the opposite effect only, e.g. omega-3 and cortisol increase the Th2/Th1 ratio ...

QUOTE: Overall, cortisol favors the development of a Th2 cytokine profile form naive cells (134). This point must not be confused with the fact that the cytokine secreting activity of established Th2-type cells is readily inhibited by cortisol. Thus, the use of cortisol analogs for conventional treatments of Th2-mediated diseases, such as eczema, asthma and hay fever may work via anti-inflammatory effects, and by reducing cytokine production by Th2-type cells (164), and yet at the same time the use of cortisol will encourage perpetuation of the underlying problem by driving newly recruited T cells towards a Th2-type response.

Psychological and physical stress activate the hypothalamic-pituitary-adrenal axis, and thereby lead to a variety of changes including increased production of cortisol. In this respect, excessive exercise and deprivation of food and sleep result in a falling ratio of DHEA to cortisol. The latter falling ratio correlates directly with a fall in delayed hypersensitivity (DTH) responsiveness (a Th1-type response marker), and there is a simultaneous rise in serum IgE levels. IgE is wholly dependent upon Th2-type cytokine production (133). This is to be expected in the light of known effects of DHEA and cortisol outlined above. A further example of the effect of stress on Th1- to Th2-type switching is the increase in antibody to Epstein-Barr virus in students reacting in a stressed manner to their exams. This virus is usually controlled by a Th1-type response and cytotoxic T cells. Loss of control results in virus replication and increased antibody production (165). UNQUOTE.

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 Message 30 of 30 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 7/24/2007 5:45 AM
That study is at: http://www.immunesupport.com/library/showarticle.cfm/ID/4181/

I did not notice where the statement about Mead acid came from - do you have a citation for it, or is it your opinion based upon what you've read? If the latter, it may not be that Mead acid is so "good," but that AA is so "bad." I've seen a lot of this Th1 to Th2 "shift" stuff, and it does look like having AA in your cells instead of Mead acid makes you more more susceptible to it. I tell people who don't know much about this that it's like putting rocket fuel in your car's gas tank.

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