 |
|
Reply
| |
The following two reports appeared on the same day, and when you read a great deal of the evidence, as I do, you come to realize that these kinds of reports always depend on the context. That is, to say something like, "antioxidants are very important and everyone should take them" is dangerous, due to its lack of specificity. Without specificity, one can simply point to a "study" and claim that he or she is "right." What is necessary is an understanding of the underlying mechanisms, and that seems to be something few people possess in the diet and health arena: QUOTE: Those phytochemicals -- natural plant-based compounds that give fruits and vegetables a reputation as healthy food -- could be unhealthy if consumed in high doses in dietary supplements, teas or other preparations, scientists in New Jersey have concluded after a review of studies on the topic. In their article, scheduled for the current issue of ACS's Chemical Research in Toxicology, a monthly journal, Chung S. Yang and colleagues analyze available data on the toxic potential of polyphenols. That group of dietary phytochemicals includes flavonoids, whose suggested beneficial effects in fruits and vegetables include prevention of heart disease and cancer. The data was from studies done in humans and laboratory animals. The report cites specific examples of toxic effects, including reports of liver, kidney, and intestinal toxicity related to consumption of high doses of green tea-based dietary supplements... UNQUOTE. SOURCE: http://www.sciencedaily.com/releases/2007/04/070430224756.htm QUOTE: According to a study in the May/June 2007 issue of the journal Ground Water, pharmaceuticals are being found in septic tanks and, consequentially, ground water due to incomplete human metabolism and excretion into the waste stream or by disposal of unused medications in the toilet or down the sink... UNQUOTE. SOURCE: http://www.sciencedaily.com/releases/2007/04/070430181148.htm |
|
|
Reply
| |
I’m not really surprised with that study. With (for instance) only 500 milligrams of vitamin C every day, there could be only one result : no results ! And then they will say that vitamin C (and other vitamins) have no utility (here : against heart attacks) !
As far the vitamin C is concerned, it’s well known that that vitamin can have utility only with at least a few grams every day.
Another (very) recent study has extra opposite conclusions !
See : http://cities.expressindia.com/fullstory.php?newsid=252337
QUOTE :
Vitamin C, E can help prevent cardio-vascular diseases, finds LU
Asit Srivastava
Lucknow, August 22: Researchers at the Biochemistry department of Lucknow University (LU) have found that Vitamin C and E can help prevent heart attacks and other cardio-vascular diseases. The clinical trials have been proved successful and the research has also been published in various International journals.
The research was carried out by a three-member team, headed by Prof M K Mishra of the varsity’s Biochemistry department. Mishra said, “In our study we have found that Vitamin (C and E) can efficiently regulate the blood and oxygen supply to heart. These vitamins also act as clot busters, thereby making the heart to function normally.�?
He added, the study has been published in various international journals on health like Molecular and Cellular Biochemistry (Canada), Bill Sardi Knowledge of Health (USA), Experimental and Clinical Cardiology (Europe), PUBMED USA (a service of the US National Library of Medicine).
The researchers term their study a boon for those who have already suffered heart attack.
The clinical trials were conducted on 65 heart patients. It showed that the vitamins considerably reduce potentially harmful free radicals formed inside the heart.
Prof Mishra explained: “Basically, when heart patients opt for angioplasty or ballooning to remove blockages in arteries, the patients become vulnerable to a burst of oxygen consumption. The heart experiences a sudden rise of oxygen supply, which in turn triggers formation of toxins. Ultimately, the toxins have an adverse effect on heart that may lead to heart attack. But, in our clinical trails we have observed that the post-heart attack patients if administered Vitamins C and E can be protected from the burst of oxygen.�?
Happy by their research study, LU researchers have worked extensively for over four years to get the breakthrough.
“We have taken up the study in 2002. Initially, we did not get the expected results. But, now as we are getting the desired results we are working to further improve our research work. The varsity is in continuous touch with renowned cardiologist of India and abroad,�?said one of the members of the research team
UNQUOTE |
|
Reply
| |
| What I often tell people is that with the billions spent on "research," this should all be known already. I think that in the future, historians will be amazed at how many "impossible dreams" were pursued with huge amounts of money while more practical information was neglected, to the point of it being unethical. |
|
Reply
| |
Hans-
I know you don't give medical advice, but we were wondering something. My boyfriend experiences what is called "HIV related fatigue", whether or not it is cause by a virus or not is up for debate but nonetheless he is still experiencing it.
His doctor put him on the anti-HIV drugs which helped somewhat with the fatigue, and then put him on Lithium which also helped him with the fatigue (which is odd since lithium tends to CAUSE fatigue by suppressing thyroid activity).
We saw that there were some current and past clinical trials of CoEnzyme Q 10 in people with HIV fatigue with some decent results.
Is there anything that we should know about using CoQ10 before having him take it? |
|
Reply
| |
| Well, small amounts seem unlikely to be a problem, but I'd be careful with large doses. Perhaps trying the smallest dosage first, for at least a week, then gradually increasing for a week at a time might be an interesting thing to try. If you do, post back here and let me know what the results are. |
|
Reply
| |
Carcinogenesis. 2007 Aug;28(8):1800-6. Epub 2007 Jun 29.
Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers.
Wilms LC, Boots AW, de Boer VC, Maas LM, Pachen DM, Gottschalk RW, Ketelslegers HB, Godschalk RW, Haenen GR, van Schooten FJ, Kleinjans JC.
Department of Health Risk Analysis and Toxicology.
Consumption of fruits and vegetables has been associated with a decrease in cancer incidence and cardiovascular disease, presumably caused by antioxidants. We designed a human intervention study to assess antioxidative and possible anti-genotoxic properties of fruit-borne antioxidants. We hypothesized that individuals bearing genetic polymorphisms for genes related to quercetin metabolism, benzo[a]pyrene metabolism, oxidative stress and DNA repair differ in their response to DNA protective effects of increased antioxidant intake. In the present study, 168 healthy volunteers consumed a blueberry/apple juice that provided 97 mg quercetin and 16 mg ascorbic acid a day. After a 4-week intervention period, plasma concentrations of quercetin and ascorbic acid and trolox equivalent antioxidant capacity (TEAC) were significantly increased. Further, we found 20% protection (P < 0.01) against ex vivo H(2)O(2)-provoked oxidative DNA damage, measured by comet assay. However, the level of ex vivo induced benzo[a]pyrene-diol-epoxide (BPDE)-DNA adducts was 28% increased upon intervention (P < 0.01). Statistical analysis of 34 biologically relevant genetic polymorphisms revealed that six significantly influenced the outcome of the intervention. Lymphocytes from individuals bearing variant genotype for Cyp1B1(*)5 seemed to benefit more than wild-types from DNA damage-protecting effects upon intervention. Variants for COMT tended to benefit less or even experienced detrimental effects from intervention. With respect to GSTT1, the effect is ambiguous; variants respond better in terms of intervention-related increase in TEAC, but wild-types benefit more from its protecting effects against oxidative DNA damage. We conclude that genotyping for relevant polymorphisms enables selecting subgroups among the general population that benefit more of DNA damage-modulating effects of micronutrients.
PMID: 17602170 |
|
Reply
| |
Hans, I have read numerous articles that exercise "properly" dosed elevates the body's natural antioxidant defenses such as SOD, catalase etc. Recently I came across a post from quite young and healthy people who after taking resveratrol supplement suffered from exercise-induced tendinitis:
http://www.imminst.org/forum/index.php?s=&act=ST&f=6&t=17543&st=0&#entry193209
This remembered me that my joint/ligament/tendon problems also started after taking a resveratrol supplement. Could it be that too much antioxidant activity from exercise combined with resveratrol results in impaired body healing response? This could weaken the tendons/ligaments which need some "inflammation" and angiogenesis to properly regenerate. Of course I was ingesting the flax seed oil at that time too what can make things only worst ... |
|
Reply
| |
| As you age, if you age "well," your SOD levels should be low and your vitamin E levels should be high. If you are being "oxidatively stressed," your SOD levels will rise and your vitamin E levels will drop. I've seen studies where the authors claim that PUFAs are healthy because they raise levels of particular antioxidants, but that's the body trying to counter higher levels of dangerous free radical activity. They seem to be unaware of the fact that the body makes adjustments - can they be totally unaware of the concept of adaptation? |
|
Reply
| |
The following is all about hormesis. Does it mean that the people on low carb diets supplementing with small amount of PUFAs may actually benefit from the induced body defenses? Of course they may be killing the effect with antioxidants at the same time as written. Personally, I would prefer the hormetic effect of exercise though.
SOURCE: http://www.sciencedaily.com/releases/2007/10/071002131149.htm
Avoiding Sweets May Spell A Longer Life, Study In Worms Suggests
Science Daily �?A new study in Cell Metabolism reveals that worms live to an older age when they are unable to process the simple sugar glucose. Glucose is a primary source of energy for the body and can be found in all major dietary carbohydrates as a component of starches and other forms of sugar, including sucrose (table sugar) and lactose.
"In the US and Europe, added sugar accounts for 15 to 20 percent of daily calories, and the breakdown of that sugar always generates glucose," said Michael Ristow of the University of Jena in Germany and the German Institute of Human Nutrition Potsdam-Rehbrücke. If the findings in worms hold for humans, it "suggests that, in healthy people, glucose may have negative effects on life span." The findings may also cast some doubt on the prevailing treatments for type 2 diabetes, all of which are aimed at lowering blood levels of glucose by increasing the amount of sugar taken up by body tissues, Ristow said.
What's more, Ristow's group further demonstrated in their report that antioxidants and vitamins given to the worms erased the life-extending benefits of sugar deprivation, raising questions about the widespread use of antioxidant supplements, according to the researchers.
In westernized countries, glucose represents a key dietary component since the most commonly ingested sugar, sucrose, contains equal amounts of glucose and fructose, the researchers noted. Nevertheless, it is a matter of debate whether glucose and other carbohydrates have a relevant effect on disease burden and mortality in humans, they said.
To begin to address the issue in the current study, the researchers exposed the nematode Caenorhabditis elegans to a chemical that blocked the worms' ability to process glucose, producing a metabolic state the researchers said resembles that of dietary glucose restriction. That treatment extended the worms' life span up to 20 percent, Ristow reported, noting that the observed gain extrapolated to humans would mean an additional 15 years of life.
Unable to depend on glucose for energy, the long-lived worms ramped up the activity of cellular powerhouses known as mitochondria to fuel their bodies, Ristow said. That mitochondrial activity led to the increased production of reactive oxygen species, sometimes referred to as free radicals. In turn, the worms' defenses against "oxidative stress" increased, the researchers found.
Free radicals are usually considered harmful, Ristow said, and scientists have generally thought that exposure to them would shorten life span. The new findings suggest that, at least in some cases, the opposite may be true.
Indeed, even when the researchers returned the worms to their normal environment, allowing them to again use glucose for energy, the worms' increased defenses and longevity persisted, Ristow said. In contrast, treatment with antioxidant vitamins prevented the oxidative stress and the defenses against it, eliminating the life-boosting effects. Ristow called the result "scary" because it means that, rather than being protective, antioxidant pills may actually leave the body more vulnerable by thwarting those natural defenses.
Ristow doesn't recommend that people toss out their multivitamins just yet, however, cautioning that his findings were made in worms. He also noted that antioxidant-rich foods, including fruits and vegetables, contain thousands of substances--many of which have yet to be identified. While scientists don't yet know what all those ingredients do, it's clear that such natural foods support "healthy pathways," Ristow said.
Cell Metab. 2007 Oct;6(4):280-93.
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress.
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M.
Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes, whereas nutritive calorie restriction increases life expectancy. We show here that increased glucose availability decreases Caenorhabditis elegans life span, while
impaired glucose metabolism extends life expectancy by inducing mitochondrial respiration. The histone deacetylase Sir2.1 is found here to be dispensable for this phenotype, whereas disruption of aak-2, a homolog of AMP-dependent kinase (AMPK), abolishes extension
of life span due to impaired glycolysis. Reduced glucose availability promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival
rates, altogether providing direct evidence for a hitherto
hypothetical concept named mitochondrial hormesis or "mitohormesis." Accordingly, treatment of nematodes with different antioxidants and vitamins prevents extension of life span. In summary, these data
indicate that glucose restriction promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of type 2 diabetes as
well as the widespread use of antioxidant supplements.
PMID: 17908557
|
|
Reply
| |
| There's just too much evidence against this notion, at the mammal, primate, or human level, to take this finding very seriously; however, I just can't tell what was actually done. I would be interested in knowing exactly what they did, but there is just not enough information presented in what you quoted. In particular, I'd like to know what the worms were fed, both control and experimental groups, how long each group lived, and if the conditions were similar to how worms live naturally. |
|
Reply
| |
I just came across a similar report that may shed light on what is occurring in the worms:
http://www.sciencedaily.com/releases/2007/10/071001171747.htm
Keep in mind that animals in the ground, where there is less oxygen, seem to have adapted in ways that seem counterintuitive (there was a similar study on the naked mole rat about a year ago, for example). I would not make diet and health decisions based upon such animal models. |
|
Reply
| |
Here's a good passage from a new report:
"...Plants rely on a complex set of bioactive volatile chemicals, which diffuse easily through the membranes of cells that produce them to communicate and interact with the outside world. These often aromatic and highly specialized compounds entice pollinators, fend off pathogens, bacteria, and leaf-munching animals alike.
Since antiquity, humans have exploited both the antimicrobial properties and pleasing aromas and flavors of plants rich in certain secondary metabolites - better known as spices - to preserve and flavor food. The food-preserving and analgesic properties of eugenol-rich cloves lured explorers like Ferdinand Magellan and Christopher Columbus across the seas in search of new routes to the Far East, which was, at the time, the sole source of cloves. Although Columbus never reached India, he did discover the Americas and, incidentally, found the source for a new spice, allspice, which contains the closely related chemical isoeugenol..."
Source: http://www.sciencedaily.com/releases/2007/10/071002213430.htm |
|
Reply
| |
Here is something new on the mole rats. It seems that they actually "live" as long as the mice when we only count their lifetime during active metabolism. (but I have seen also different article showing that the longevity of Queen Bee is mediated by more saturated lipid membranes induced by different feeding regime/supplementation - the royal jelly link).
SOURCE: http://news-info.wustl.edu/tips/page/normal/10217.html
Ugly duckling mole rats might hold key to longevity
Methusalah of the mammalian kingdom
By Erin Fults
Oct. 4, 2007 -- Who would have thought that the secrets to long life might exist in the naked, wrinkled body of one of the world's ugliest animals? Probably not many, but current research may be leading seekers of the Fountain of Youth to a strange little beast �?the naked mole rat.
The naked mole rat is certainly not one of nature's cuddliest species. These small rodents are hairless, wrinkled, blind and buck-toothed. Stan Braude, Ph.D., lecturer in biology in Arts & Sciences at Washington University in St. Louis, however, is attracted to these animals and has been studying them for over 25 years, with about 20 of those years being in the field in Kenya.
Braude is currently working on a new book that will serve as a synthetic review of the past 20 years of research on naked mole rats. While various research has been conducted on naked mole rats in a lab setting, Braude and his students are the only researchers out in the wild with them.
"I make the case [in my book] that if you really want to understand the lab work you also have to know what these animals are doing in the wild," said Braude.
Some of the "hottest" research on naked mole rats today concerns senescence, or aging. Naked mole rats in the lab have reached up to 28 years of age. And it's not just the controlled environments of their captivity that are doing this. Braude has observed mole rats in the wild that are 17 years and older. But these are the breeders. Lab researchers didn't realize that in the wild workers only live two or three years.
"For a rodent of this size, they are ridiculously long-lived," said Braude.
Hairless wonder
A key component in the aging of any species is oxidative damage, where the cells accrue damage from poisons, environmental toxins and other effects throughout life. In such a long-lived rodent, it was thought that naked mole rats had a very efficient way of repairing oxidative damage. This wasn't the case, however, and current theory points to the strange metabolism of this hairless wonder.
Naked mole rats appear to deal with oxidative stress in pulses, largely due to their ability to essentially shut down their metabolism when there are hardships, such as lack of food. In this way, mole rats may be able to rid their body of harmful reducing agents and poisons more easily during these metabolic pulses.
"Another way to think of it is, their gross life span might be 28 years, but their metabolism is going in these short bursts so maybe the net damage is only 3 or 4 years of net use," said Braude. "They're living their life in pulses."
Shelley Buffenstein, Ph.D., of the University of Texas, San Antonio, is one of the researchers leading the way in senescence research and the naked mole rat. She is hoping to accompany Braude to Kenya in 2009 to observe mole rats in their wild habitat.
So how are these naked guys going to help us? Parrots and sea turtles are also long-lived, and perhaps one day humans will be able to harness whatever biological process these animals are using and apply it to our own lives.
"If we understand how these different species do it, then the next step is to figure out how we can get those benefits with either drug treatments or changing diet or changing lifestyle," says Braude. "It's nice that we have a mammal that is also [living long], so there' s hope that it's not just a bird and reptile thing."
The senescence of naked mole rats is not Braude's primary concentration. He considers himself a behavioral ecologist and takes his perspectives on physiology and applies it to these animals in the wild. He was originally drawn to these animals, as were many researchers at the time, because of their eusocial behavior. Naked mole rats, like bees and ants, have a queen and workers.
Kidnapped! By a naked mole rat, no less
During his time with naked mole rats in Kenya, Braude has observed many traits and behaviors that make this animal unique. Naked mole rats in nature kidnap pups from other colonies and bring them back to serve as workers in their own tunnels; naked mole rats will invade neighboring colonies and fight for hostile takeover; and when naked mole rats disperse, or leave the colony to found a new one, they have often been found up to two kilometers away.
"They're blind, they're hairless, they're small, but they're running…two kilometers from where they're born when it's time to disperse. That's pretty dramatic," Braude said.
In the wild, Braude has survived a leopard jumping past him to maul the man standing next to him in the back of a pickup truck and an angry cobra in a sack of potatoes he reached into. But "on a good day" he describes his work as "ice fishing at the equator," as he waits for naked mole rats to emerge from their burrows.
Braude is writing a synthetic monograph that will pull together all the different threads �?from the ecology in the wild, from the behavior, from the physiology �?with the unique perspective of living with these animals in their natural environment for almost 20 years.
Braude has also written an illustrated children's book about the day in the life of a naked mole rat. Imagine that as a bedtime story. |
|
Reply
| |
This new palladium antioxidant seems to be too good to be true. What do you think Hans about the molecular mechanism they are claiming?
SOURCE: http://www.vrp.com/articles.aspx?page=LIST&ProdID=1729&zType=2
Poly-MVA®: Support for Mutagenic Concerns
Immune-Enhancing Palladium Compound
By Albert Sanchez, Ed.S., Ph.D.
Electricity is usually associated with plugging a cord into an outlet. However, our body’s cells also operate through an electrochemical process. Research indicates that a compound known as Poly-MVA® can influence this electrochemical process occurring in the body, consequently “electrocuting�?cancer cells while leaving healthy cells vibrant and alive. And while I use the term electrocuting to describe this process, it is less destructive to the human body than conventional ways of destroying cancer cells. In fact, it’s highly beneficial.[1]
Poly-MVA contains a patented type of palladium lipoic complex composed of the mineral palladium bonded with the antioxidant lipoic acid. Poly-MVA also contains vitamins, minerals and amino acids. This unique compound promotes energy production at the cellular level in both healthy individuals and those with cancer. Cancer cells operate in anaerobic conditions (without oxygen) and Poly-MVA appears to target and kill these anaerobic cells in part through its ability to change cells�?electrochemical circuitry.[1] In addition, rather than simply destroying free radicals, Poly-MVA converts them into energy, indicating its potential uses may expand beyond that of an anti-mutagenic agent.
In this article, I will discuss how a scientist created Poly-MVA. I will also discuss some of Poly-MVA’s ingredients, its mechanism of action and how it may support both individuals with mutagenic concerns and healthy individuals. However, first I will explain my personal connection to the Poly-MVA story. My wife, Julia Sanchez, died of colon cancer in 1972 at the age of 34. At the time of her death, I was a school principal in Anaheim, Calif. I raised our four children alone. I will always be inspired by her memory. Her death, however, was not in vain: I swore that I would never rest until the disease that had taken her life was vanquished. For this reason, I have explored less invasive cancer treatment modalities and am convinced that Poly-MVA can play a part in cancer therapy. Consequently, I purchased Poly-MVA for distribution to cancer patients.
The Poly-MVA Story
Dr. Merrill Garnett, a dentist-turned biochemist and head of the Garnett McKeen Laboratory in Stony Brook, New York, created palladium lipoic complexes after decades of research.
Dr. Garnett’s research is based on the theory that all normally-developed cells contain an inward directed energy flow. He and his son, Wade, have looked for those pathways that alter electron flow in the cell, from the point of view that normal cell development requires normal energy flow.
In laboratory experiments, Dr. Garnett found that by introducing synthetic mimics of electric pathways, dysfunctional cells were destroyed selectively—in other words, abnormal cells were targeted for destruction while healthy cells thrived. Based on this theory, Dr. Garnett began the search to find a compound that would restore healthy pathways for growth and normal development within the cells—pathways missing or deficient in dysfunctional cells.
Specifically, he searched for what’s called a metallo-organic compound that would act as a molecular shunt to restore the cells�?healthy energetics. After more than 40 years of research and testing some 20,000 compounds, Dr. Garnett discovered that palladium, when combined with lipoic acid, vitamin B12 and thiamine, created an extremely useful and safe cellular nutrient. Subsequent toxicity tests have shown that palladium lipoic complexes are completely safe and nontoxic.[2]
Mechanisms of Action
Poly-MVA is a uniquely formulated dietary supplement containing a proprietary blend of palladium bonded to alpha-lipoic acid (referred to as palladium lipoic complexes). The supplement also contains vitamins A, B1 and B12, formyl-methionine, acetyl cysteine, plus trace amounts of molybdenum, rhodium and ruthenium. This formulation is designed to provide energy for compromised body systems by changing the electrical potential of human cells and increasing DNA’s charge density within the cell. Consequently, Poly-MVA may assist in boosting immune response and healing damaged cells.
Poly-MVA is non-toxic due to the proprietary manufacturing process by which palladium is sequestered within lipoic acid. The formulation of palladium lipoic complexes with other vitamins, minerals and amino acids provides considerable nutritional support, helping to enable optimum functioning of essential body systems.
The palladium lipoic complexes in Poly-MVA work in novel ways that do not harm the body as a whole—only the cancer cells specifically, partially by converting free radicals into a usable form of energy. (For this reason, large amounts of the antioxidant vitamin C shouldn’t be given at the same time as Poly-MVA. It is recommended that there be at least a four-hour interval between consumption of large quantities of antioxidants and Poly-MVA since antioxidants scavenge and destroy free radicals, whereas Poly-MVA turns them into energy.)
In cancer, gene damage is caused by adducts, chemicals that attach to the gene and disturb its function. Palladium lipoic complexes are essentially enzymes known as nucleotide reductases that help remove these carcinogenic adducts. Due to these and other properties, the palladium lipoic complexes found in Poly-MVA increase muscle strength, raise energy levels, protect against extracellular LDL, chelate heavy metals, reduce need for pain medication, improve appetite and slow the aging process.[3]
Cellular metabolism is an electrochemical process. When the body produces energy, it is released along the electron transport chain in the form of voltage jumps. That electrochemical energy is captured in reactions that preserve it in the form of adenosine triphosphate, the energy currency of the body. Splitting ATP into adenosine diphosphate and a free phosphate molecule then fills the body’s energy needs.
Dr. Garnett believed that electron transfer somehow held the key to understanding the genetic signaling that would transform cancer cells into healthy ones. He sought to create a sort of “liquid transistor�?consisting of a metal and an organic compound (a metallo-organic compound). This liquid transistor would act as an enzyme and affect the electron transfer to DNA. He found that a specific combination of the metal palladium and the organic molecule alpha-lipoic acid rapidly and efficiently transferred electron charges to DNA. In other words, Poly-MVA works in cancer cells by transferring excess electrons from membrane fatty acids to DNA via the mitochondria. Therefore, it can both quench radicals as well as provide energy to the mitochondria.[2,4-6]
Transferring the charge in and out of the DNA with the palladium lipoic complexes changes the DNA charge as well as the charge in all the cell membranes. This is what is already happening in the normal cell, in the same specific range. Triggering this normal charge in tumors provides therapy by way of membrane modification. Cell culture and animal experiments in mice with cancerous tumors indicated that the palladium-alpha-lipoic-acid-thiamine compound was toxic to cancer cells. In one experiment, mice treated with this compound did not die from a form of cancer that was lethal to mice not treated with the compound. Further analysis showed that the compound selectively eliminated cancerous cells in the animals while leaving healthy cells alone.[2]
Pharmakon Laboratories also performed animal studies to determine the safety and effectiveness of palladium lipoic complexes in the treatment of glioblastoma, a fast-growing brain cancer. At the beginning of the study, glioblastoma tumor cells were injected into mice. When tumors had grown to 200 to 400 millimeters in volume, the mice were divided into eight groups of ten. Four groups were given daily intravenous doses of either the palladium lipoic complexes or a placebo. Four groups were tube fed palladium lipoic complexes or a placebo. The animals administered the palladium lipoic complexes received daily doses of 2, 1.5 or 1 milligrams per animal for four weeks. Mice that died were dissected and tumor volume was compared between groups.
In mice that received the palladium lipoic complexes glioblastoma tumor cell growth was significantly reduced. All of the intravenously treated mice showed significant reduction in tumor size compared to the placebo. Of the mice given the palladium lipoic complexes through tube feeding, dosages of 1 to 20 milligrams per mouse—a dose comparable to that used in humans with cancer—significantly shrank tumor size.[7]
Oncological surgeon Rudolf E. Falk presented the first report of clinical studies of Poly-MVA at the Adjuvant Nutrition in Cancer Treatment Symposium in March 1994. In his work at the University of Toronto, Dr. Falk administered Poly-MVA intravenously to 95 patients suffering from cancers of the breast, lung, colon, rectum, prostate, pancreas, ovary, skin (malignant melanoma) and brain. Ninety percent of the subjects had failed to improve on virtually all available conventional therapy. During Poly-MVA treatment, the subjects also received moderate doses of chemotherapy.
Only 20 to 60 percent of the patients would be expected to survive an average of another six months. Nine months after being treated with the intravenous Poly-MVA, however, 90 percent of the subjects were still alive.[2] Current studies on stage IV cancers performed by certified board oncologists reveal an improvement of 77 percent in Poly-MVA-treated subjects.[8]
The animal tube feeding experiment mentioned above and the results achieved by clinicians administering Poly-MVA, indicate that oral supplementation with Poly-MVA would be expected to achieve the same results.
Palladium
Palladium is the binding force and center of all the palladium lipoic complexes. Dr. Garnett chose palladium for specific reasons. He needed a catalyst to reestablish the normal functions that had been lost in the cancer cells. The amazing properties of palladium, Garnett discovered, were just right for the task. As an excellent catalyst for oxygen and hydrogen, it could, under the right circumstances, absorb more than 900 times its volume of hydrogen.
Dr. Garnett used the palladium to strengthen the power of the other molecules, similarly to the way iron is used to hold the active parts of hemoglobin.[2]
Lipoic Acid
Lipoic acid is one of the natural substances used to form palladium lipoic complexes. The unusually powerful antioxidant effect found in palladium lipoic complexes can be partly attributed to its lipoic acid fraction. Since this naturally occurring acid is soluble in both fat and water, palladium lipoic complexes are able to pass across cell membranes and work intracellularly.
When lipoic acid is connected to an electrically charged metal substrate, and joined with various B vitamins, the activated B12 increases the biological activity of the molecule thereby performing that difficult journey across the blood-brain barrier. The resulting complex, in addition to crossing the blood brain barrier, can easily and safely travel throughout the body and into every cell. This quality indicates that palladium lipoic complexes may be an excellent protocol to use in cases of brain cancer—along with breast, prostate, colon, lung, and stomach cancer.[2]
Molybdenum
Molybdenum is an essential trace mineral crucial for the regulation of pH in the body. Cancerous cells, depleted of oxygen, also tend to be excessively acidic. Anaerobic metabolism produces acid and overly acidic cells are undergoing stress.[2]
Rhodium and Ruthenium
Rhodium, a rare earth metal noted for its low electrical resistance and high corrosion resistance, is used as a catalyst for many chemical processes. Ruthenium is another transition metal of the platinum group used to harden and increase the corrosion resistance of titanium. Ruthenium/molybdenum alloys have been found to be superconductive.[2]
Other Uses for Poly-MVA
A study published in September 2004 indicates that administration of Poly-MVA may be a potent neuroprotective agent for victims of transient ischemic attack (TIA), cardiac arrest, anesthetic accidents or drowning.[9] According to Frank Antonawich, one of the researchers in this study, Poly-MVA’s neuroprotective properties make it extremely effective for stroke.
In addition, clinical experience indicates it may support the skin health of psoriasis patients.[10] Clinicians have also successfully used Poly-MVA in patients with multiple sclerosis and lupus.[2] By enhancing the liver’s function, Poly-MVA helps move blood out of the pelvis via the portal vein, a process beneficial in endometriosis.[2] Poly-MVA also can be used in pets. |
|
Reply
| |
| Sounds like a bunch of assumptions piled upon each other, leading to the claim that you should take this stuff. Of course, without PUFAs in the diet (along with a few other things), and with the right things in your diet, there is not likely to be any cancer problems in the first place. Notice how one "study" mentioned is not a cure, but a way to keep people alive for a little while longer. Similar results are certainly possible with massive amounts of fish oil supplements, but again, since the cause of most cancers are known (i.e., AA metabolites), it's much more intelligent and practical to just cut off this "cancer fuel." |
|
Reply
| |
Here's an undeniable "pollution" problem:
"Researchers report effectiveness of a powerful, environmentally-friendly catalyst in destruction of various estrogens that currently escape complete removal in our wastewater treatment plants.
In the new study, Nancy Shappell and colleagues explain that endocrine disruptors, both natural hormones and hormone-like compounds, have been detected in the surface waters. Many of these endocrine disruptors have estrogenic activity..."
Source: http://www.sciencedaily.com/releases/2008/01/080128120622.htm |
|
|
Free Forum Hosting
Important Announcement
First
Return to Nutrition