Americans consume huge amounts of calcium yet have major bone loss issues, unlike some peoples who don't consume much calcium-rich food. Why? Again, it's about "chronic inflammation," which is another way of saying that one has arachidonic acid in one's cells:
QUOTE: ...Beyond its control over immune cells, TNF alpha also influences bone mass. Human bone is continually regenerated to maintain strength. Under the control of signaling molecules which include TNF alpha, two cell types, balanced against each other, make bone recycling possible. Osteoclasts break down aging bone to make way for new bone, while osteoblasts build new bone at the sites where osteoclasts have removed it. Going into the study, the field understood that TNF alpha decreases the number of bone-building osteoblasts, but not how. The current study provides the first direct proof that the TNF alpha affects osteoblasts through an enzyme called Smad Ubiquitin Regulatory Factor 1 (Smurf1), which in turn shuts down two proteins that would otherwise drive bone-building... UNQUOTE.
If you've read the essays on this site, you know all about arachidonic acid and TNF alpha.
Source: http://www.sciencedaily.com/releases/2008/08/080820163233.htm |
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