Here's a recent study on this subject:

 

Free Radic Biol Med. 2006 Dec 1;41(11):1678-1683. Epub 2006 Sep 8.

TITLE:  Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease.

QUOTE:  Oxidant stress is widely believed to participate in cardiovascular disease pathogenesis.... Of the markers monitored, only 9-HETE and F(2)-isoprostanes, both products of free radical-mediated arachidonic acid oxidation, were significantly elevated in patients with angiographically defined CAD ...Systemic levels of 9-HETE and F(2)-isoprostanes are independently associated with angiographic evidence of CAD and appear superior to other specific oxidation products of arachidonic and linoleic acids as predictors of the presence of angiographically evident coronary artery disease.  UNQUOTE.

 

The only problem with this abstract, as far as I can tell, is that they say this mechanism is widely believed to participate in the "disease," and yet I almost always hear "experts" talk about "saturated fat" causing heart disease.  The reality, of course, is that saturated fatty acids cannot be made into these molecules (the "markers" that the researchers refer to).