Pappy John,
I have my brochures printed (or copied actually) at Staples on their color laser copier. It's on 24# Hammermill LaserJet paper. Nice quality, bright white and smooth.
It's not cheap but the price goes down with quantity. You should probably call around to different copy shops in your area and get pricing for 50,100, & 250 two sided color. I don't usually get more than 50-100 printed at a time.
It's probably cheaper to print them off on a good quality paper (24-28#) on your inkjet but you'll sacrifice quality.
I also had some B&W laser copies made at a lower price as a back up but you loose the visual quality that color offers. At the price of color, I don't leave a whole lot of them out, just place one here and there but if I spend time talking to someone who seems interested, I hand them a brochure. I keep my business cards out in bulk only.
If you've got some graphic arts background and a program that can print out color seperates (CMYK), you might also want to call around to commercial printers for 4 color process printing but they won't print just 100 or 250. Probably wouldn't print any less than 1,000 otherwise your price would not be justified.
If you design a brochure and print it out on an inkjet, take a copy of it with you to a printer and ask them what they suggest. I'm sure they could give you a few options and most are very willing to help. If you have a local publisher, the ones who print the local free papers, sometimes they also offer printing services.
Hope this info helps you and others thinking about producing a brochure.
Linster