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Nutrition : Omega-3 Kills Mead Acid
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 Message 1 of 15 in Discussion 
From: MSN Nicknamerensielk  (Original Message)Sent: 5/21/2008 7:01 AM
http://www.jlr.org/cgi/content/full/46/4/706#FIG4

Olive oil feeding produced about a 1:10 ratio of Mead Acid to Arachidonic Acid (0.1 triene/tetraene ratio). Fish oil totally kills Mead Acid. It shuts down the enzymes needed to make it. Based on Modern Nutrition in Health and Disease, I have learned that a 10:1 ratio of MUFA to PUFA will increase the Mead Acid to AA ratio. I feel the ratios are where we should be concentrating most of our attention.

Macadamia oil has a very high MUFA/PUFA ratio (as much as 40:1). Fatty liver has a 32:1 M/P ratio. High-fat beef is a good choice, with about 16-18:1 M/P ratio. I would not cook it more than medium. Pref rare or raw. Cocoa butter has an 11:1 MUFA/PUFA ratio. Beef suet has a 10:1 ratio. Those seem like good fats. If you have to eat sunflower oil, it would be best to get the high-oleic variety since it's low in PUFAs (about 4%). High oleic safflower oil tends to be higher, like 14%. The best are coconut and macadamia IMO, with 1-2% PUFAs typically, and sometimes even less.

The ratio of fatty acids is very important. I think we should be focusing mainly on SFAs and MUFAs, with PUFAs limited to an increasing degree as their number of double bonds goes up and the omega-number goes down. I eat shellfish and dry fish (1-2% fat by weight) occasionally. Wild fish has 50% the PUFAs that farm-raised does. But I don't eat a lot of fish, due to high prices, over-fishing, and pollution.


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 Message 2 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/21/2008 7:01 PM
Basically, I've been experimenting on myself since 2001, unless you count the "vegan" diet I was on for the 12 years before that. I found that once I added gelatin, along with the other things I needed (like stomach acid supplements, which I don't take any more), everything "normalized." My "educated guess" is that if people ingest a little nutritional yeast and gelatin each day, they don't ever have to eat "meat," which can be very dangerous, especially if cooked and eating with more than small amounts of PUFAs (which is common in the USA today, of course). Instead, I eat non-cooked sources of high quality protein, such as cheese.

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 Message 3 of 15 in Discussion 
From: MSN Nicknametaka00381Sent: 5/22/2008 2:35 AM
Do you think that eating raw fish (sushi) which does contain some DHA/EPA would also block the Mead acid synthesis? Also as for the "wild" grass fed animals it's common belief that they are rich in Omega-3s (compared to grain fed ones).

In the cited paper it looks that PPARalpha stimulation upregulates the machinery leading to the Mead acid production (given the proper diet low in linoleic and alpha-linolenic acids). Which dietary/lifestyle factors could upregulate the PPARalpha? I have seen lot of talks about the PPARgamma but not this one.

Thanks for this interesting find!

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 Message 4 of 15 in Discussion 
From: MSN NicknamerensielkSent: 5/22/2008 5:05 AM
I don't think we need to eat a lot of meat, per se, but the fat is useful for some people. You can get strips of fat free at most groceries, even health food stores, because they trim it off of their meat. You could eat this fat raw if you wanted, but I think light cooking is safe (medium or less), as long as you eat the food immediately and don't re-use the fat. Some of the native American tribes lived on pemmican, which is made from raw lean meat dried in the sun and rendered animal fat. They did not have modern diseases, and the pemmican would remain fresh for years (or decades) if stored properly.

PUFA oils are much more dangerous, IMO, even raw. While using raw flaxseed oil years ago on a raw diet (including raw meat), I got sick easily when exposed to cold air/water, and sick people. I also stayed sick longer, too. this made sense when I realized that omega-3 fats were immune suppressive and probably worse than omega-6 fats, although it's best to keep them both at very low levels probably.

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 Message 5 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/23/2008 2:30 PM
Hans, when you eat cheese, is this like the main course of your meal?
 
Do you eat this plain or do you have recipes or different ways to prepare it?
 
I'm looking for ways to increase my cheese consumption while lowering my meat consumption for health reasons.
 
I'm also looking to lose a few pounds of fat while hopefully adding some muscle but trying to eat healthy (according the to high sat. fat, low PUFA protocol espoused here, on Ray Peat's site, AV-Skeptics, etc.) really flies in the face of what is typically recommended for weight loss.
 
I love cheese melted on various foods but I guess that would defeat the purpose, huh?
 
I was looking for information on dairy consumption in different countries, especially in France, and I found that the French had one of the highest butter and cheese consumption rates but they were one of the lowest in actual milk consumption, which I found quite interesting.
 
Thanks Hans,
 
Will

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 Message 6 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/23/2008 6:42 PM
I usually eat cheese with a little pickled cabbage, but I "rotate" my food to make the meal interesting without cooking. So I'll take a small bite of cheese and eat it with a very small amount of the cabbage (and a tiny amount of nutritional yeast), but instead of continuing to eat the cheese, I'll eat a sweet food, like a small bite of a cookie, with shredded coconut, ricotta cheese mixed with cold coffee (and salt to taste), a couple of bran flakes, and a small slice of banana. The only "problem" is that I need a lot of space to spread this all out on the kitchen table, which might be a problem at work, for example. You can also cook some pasta, and while that's cooking, create a sauce with ricotta, a tablespoon of sherry, a little butter, and some herbs (basil, pepper, onion & garlic powder, parsley, etc.). Only use low heat, and keep stirring. Then drain the pot with the cooked pasta and add it to the sauce. Raise the temperature up to low/medium, and stir often. After a minute or so, you can add grated cheese, like Parmesan/Romano mix, and also add tiny slivers of Provolone. When you see that the provolone has melted, it's ready to eat. I keep it in the saucepan and put a lid on it while I'm eating, because it's not very hot and will cool off quickly, unless you really "wolf down" your food.

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 Message 7 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/27/2008 5:33 AM
Thanks for the response Hans.
 
From that, I take it that heating the cheese causes anything detrimental to the cheese which is good news for me.
 
I am going to try the ricotta cheese recipe but I'll probably have that with some sprouted breda instead of pasta because a pasta meal makes me fatigued to the point where I HAVE to sleep right after eating and then when I wake up, I feel like my eyes are swollen shut.
 
A smaller amount of pasta or more of another starchy carb will give me horrible bags under my eyes when I wake up the following morning...weird.

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 Message 8 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/27/2008 5:28 PM
You seem to be having some sort of metabolic issue. I'd be interested in knowing about your diet and health. Your symptoms don't seem "normal," and it seems like your body is getting really stressed over something that should not be so stressful. Are you eating way too many calories? Are you going for long periods of time before each meal? If not, can you think of anything else that you are doing that is unusual?

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 Message 9 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/27/2008 7:41 PM
Well, I'll try to be brief and complete at the same time (doesn't always work!).
 
I grew up on CapNCrunch and other disasterous cereals and foods.  My mom would start dinner at 4:45 and dinner would be on the table at 5:00, so you can imagine the instant crap that we ate (BTW both of my parents have passed away from different cancers...never made it out their 60's).
 
I was always a gluttonous eater, always finishing everything at every meal...I would take 10 peanut butter and jelly sandwiches to school for lunch when I took my lunch and when I ate the school lunch, I would order 2 lunches...I could eat 10 McD's cheeseburgers but I would regularly eat around 6.
 
Funny thing is, I was always skinny and got picked on, so I started lifting weights in the 5th grade and by 8th grade I never got picked on again. I enjoyed working out so I ran and worked out all the time so I never had to worry about getting fat from eating so much. I wrestled in high school and took a few martial arts too.
 
At 20 yo, I went to the family doc for a checkup and my blood pressure was 180/100 and he was going to put me on meds. Instead I quit McD's and the other fast food places and got it down to a reasonable level to be able to avoid the meds.
 
About 5 yrs ago, while in grad school, working full-time, family etc., I was getting a little heavy but not really able to undertake any kind of training to lose the weight, I stumbled across the Warrior Diet (1 large meal a day) and then intermittent fasting.  I lost a good bit of weight doing this over the course of 3 of the last 5 years. I'm going to be 42 next month).
 
Everything was going OK but then my weight and bodyfat started creeping up again.  I started putting in my food intake into the CRON-O-METER which is a diet tracker program that you can get online for free and I was only eating about 1500 calories a day.  I started looking things up and doing some testing on myself and I had almost every symptom of hypothyroidism. I emailed Ray Peat and he gave me some good advice like eating more frequently, consuming milk and OJ, consuming gelatinous broths, not avoiding carbs, etc. 
 
I asked him about pregnenolone and he said that he used it and it appeared to be safe, so I started taking that. I have my morning temperature up to around 97.4 to 97.7F which is probably just above what indicates hypothyroidism, (it had been in the 96's and was very erratic which indicates an adrenal weakness, so your assessment that my body was being overstressed would seem quite accurate) so I'm doing better now.
 
But now after going from one 1500 calorie meal to eating throughout the day, I'm almost 200 pounds (192 to 196)...I was about 177 in Feb of this year. I'm in kind of a state of confusion as to how to lose the weight. Ray Peat says not to go low-carb because it's not good for your thyroid but when I was a low-carb guy, I used to carry 6% to 10% bodyfat without any trouble at all.  I tried the bodybuilders kind of diet, eating every 3 hours, low fat, mod protein, hi carb but I didn't feel good and I couldn't let go of my beliefs that saturated fat is best, MUFAs are good, and restrict PUFAs, so I couldn't fully immerse myself into that diet anyhow.
 
I'm wandering aimlessly, diet-wise, right now, eating eggs or raising bran or oatmeal for breakfast, a meat, carrots, and some type of potato for dinner, and previous day's leftovers and fruit or macadamia nuts in between. I would like to reduce my meat intake and increase my fruit intake (low meat, high fruit has been associated with a reduced incidence of polyps according to a study from UNC State, http://jn.nutrition.org/cgi/content/full/137/4/999 , my mom died of colorectal cancer) but I don't know how that will work with muscle building and fat loss. According to "The Fiber Menace" maybe I'm not doing the best thing by eating oatmeal or raisin bran. Right now, I'm lost.
 
I haven't eaten pasta in a LONG time so I couldn't tell you how I would respond to it now.
 
So much for brevity...thanks.

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 Message 10 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/28/2008 7:33 PM
Okay, first thing for me to consider is, what are you health problems (anything other than weight gain?)? Have you seen a doctor recently, gotten the full "workup" of tests? If so, what did he or she suggest? Once I know this, I can say more. At this point, I think you need to get on one plan and follow it for at least 3 to 4 months, and see how you are at that point. This is basically what I had to do, and it's really discouraging at times, but I don't see any other way. If you choose to follow my diet and supplement plan, keep in mind that you may need to make adjustments. For example, I was taking small amounts of potassium salt, but noticed PVCs (irregular heart beats), which I had had in the past. I eliminated the very small amounts of this substance and within a week or so the PVCs were gone. For the time being, let me know about your concerns and your doctor's advice and then I'll be more specific.

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 Message 11 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/28/2008 8:05 PM
My biggest problem is hypothyroid, not diagnosed by a doctor, but by symptom and self testing (morning temperature which I take every day). I believe that I also have weak adrenals (self tested by shining a light onto the side of the eye in a dark room and if the pupils constrict and then open up or fluctuate between open and constricted, your adrenals are considered weak).  I got much of this from http://www.stopthethyroidmadness.com/?PHPSESSID=adb682cfafb4f96eab854f86df74d1a9 , which is a great resource for hypothyroidism. Pretty much all of the symptoms that go along with hypothyroidism such as fatique, weight gain, brain fog, muscle weakness (lost strength in my weight training workouts, inability to complete workouts), etc., although I have been working on the hypothyroidism and the symptoms are slightly better.
 
The last couple of trips to the doctor I had normal blood pressure for the first time in my life: usually 145/85 but those past two visits were 120/80. But my cholesterol was now high. It had been around 210 to 225 but this last time it was closer to 300 (I believe that I read in a Ray Peat article that high cholesterol was actually diagnostic of hypothyroidism).
 
Since my doc is a cardiologist, he was thrilled that my blood pressure was actually 120/80.
 
That seems to be the bulk of it.
 
I have abandoned the bodybuilder diet because I felt bad and have gone back to a higher fat diet (ex: this morning 3 fried eggs in coconut oil, 8 oz of OJ not from concentrate, lunch, some leftover steak, about 3 oz., some pineapple, and a square of Lindt dark chocolate 70%, and a couple of handfulls of macadamia nuts), so this is how I'm eating in the interim for now.  I feel better eating this way than the former.
 
Thanks for taking the time Hans.
 
Will

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 Message 12 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/29/2008 5:52 PM
Okay, if you read the material on Peat's site, why haven't you gone to a doctor seeking a prescription for thyroid medication? This is a situation where you may need help from "traditional medicine" for a while, and once you get that problem straight (for example, if it's the thyroid), then you can dabble with other things, like seeing what a little B complex with each meal does.

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 Message 13 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/29/2008 6:45 PM
I was hesitant to get into the thyroid discussion with my doc after reading so many horror stories about blood tests not being accurate for thyroid diagnosis, docs unwilling to prescribe Armour Thyroid based on these inaccurate test results, etc.
 
I guess that I'll have that discussion with my doc at my next appointment coming up in a month or so.
 
Thanks Hans.

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 Message 14 of 15 in Discussion 
From: MSN NicknameHansSelyeWasCorrectSent: 5/30/2008 5:46 PM
In the meantime, you might want to read the information available at:

http://www.ithyroid.com

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 Message 15 of 15 in Discussion 
From: MSN NicknameThe_Evil_Future_MutantSent: 5/30/2008 9:47 PM
Thanks for that website...I saved that one in my favorites!
 
Thanks Hans!

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