A new report is consistent with the oxidative stress/inflammation explanation, though, as usual, the researchers are more interested in the idea of inhibiting a protetin that is expressed in larger than normal amounts when the cell is under certain kinds of stress, rather than preventing the stress in the first place:
QUOTE: Dr. Hidefumi Waki, working in a research group led by Professor Julian Paton, has found a novel role for the protein, JAM-1 (junctional adhesion molecule-1), which is located in the walls of blood vessels in the brain.
JAM-1 traps white blood cells called leukocytes which, once trapped, can cause inflammation and may obstruct blood flow, resulting in poor oxygen supply to the brain. This has led to the idea that high blood pressure -- hypertension -- is an inflammatory vascular disease of the brain.
One in three people in the UK are likely to develop hypertension, and with 600 million people affected world wide, it is of pandemic proportions. UNQUOTE.
SOURCE: http://www.sciencedaily.com/releases/2007/04/070415110120.htm |