Coocoochee and her family joined the friendly camp of Shawnee chief Blue Jacket, and settled in his village on the west bank of the Scioto River. Most of her life was lived among the Shawnee, and is unusually documented because of Oliver Spencer �?a white man who was captured as an 11 year old boy by Coocoochee's son White Loon, near what is now Cincinnati. Spencer lived in the Shawnee camp for only 7 months, but he maintained contact with Coocoochee and her family throughout his lifetime.

Soon after joining Chief Blue Jacket's people, Coocoochee was taught medicine ways, herbal healing, and the functions of the medicine woman. She became quite skilled and respected for her considerable healing talents. Additionally, she was a gifted visionary, and her advice was sought on many occasions by the Tribal Council for various matters concerning the welfare of the people. She was held in a position of high respect.

Only 5 years after settling into the camp by the Scioto River, word came to Chief Blue Jacket of massive destruction taking place in the Shawnee villages of the Muskingum Valley under the direction of Virginia Governor, Lord Dunmore. While the encampment of Chief Blue Jacket escaped destruction, it became clear that they would no longer be safe. When word reached the chief of the beginning of the American Revolution, he moved his people, including Coocoochee and her family, to the Mad River along the Ohio/Kentucky frontier. Upon settling at this location, Chief Blue Jacket's village became a refuge for many Native tribes fleeing the white man's war and it became a true inter-tribal settlement.

While it was hoped that peace would return to the Natives in the area following the end of the war, this proved not to be the case. Many had now seen the lush land and plentiful game of the region. Settlers and adventurers from Kentucky pushed ever onward into the Native territories, forcing Chief Blue Jacket and his people to move once again in search of a peaceful location for their settlement. Picking up still more displaced Natives along their journey, Chief Blue Jacket and his group were welcomed by the towns of the Miami settled along the Maumee River near Ft. Wayne, Indiana. They established their encampment near the friendly Miami, but were to only have 3 years of life in this area before the Miami towns and surrounding area were destroyed and burned at the order of General Josiah Harmar. Coocoochee's husband was killed during this raid.

Once again, Chief Blue Jacket, his people, and the survivors of the raid including the widowed Coocoochee, were forced to move in search of a homeland. They traveled along the Maumee River, and were taken in by a large inter-tribal group known as the "Glaize" at what is now Defiance, Ohio. However, after 4 years with the Glaize, a raid by General Wayne (known as the Battle of Fallen Timbers) forced this large community to scatter in order to survive. Only passing word of Coocoochee was occasionally heard after this final onslaught, and information gathered from her children indicates that she died early in the 19th century before the beginning of the War of 1812.