This is PART TWO of two pages of medication information. Be sure to view part one. Sorry that it's so wide, but am unable to increase length on this page.
SOM-Medicines used by group members - Part two - FOR INFORMATIONAL PURPOSES ONLY this information is compiled from drug company information and empirical information from group members, and is edited and partial, and to be fully researched by the patient before considering use. SEE YOUR PHYSICIAN.
PART TWO
Drug Generic Trade names | Manufacturer | Contraindications | Possible adverse reactions | Additional information |
Alprazolam
Xanax | Generic
Purepac Geneva Brand Pharmacia Upjohn | Abrupt discontinuation, depression, elderly, psychosis, pulmonary disease, renal impairment, respiratory depression, sleep apnea, substance abuse, pregnancy | Agitation, amnesia, anorexia, appetite stimulation, confusion, constipation, dizziness, drowsiness, fatigue, hyper salivation, irritability, menstrual irregularity, tolerance, withdrawal | Acts at level of limbic, thalamic, hypothalamic regions of CNS. Mediated through inhibitory neurotransmitter gammaa-aminobutyric acid (GABA). Inhibits the ascending reticular activating system. |
Carbamazepine
Tegretol Carbatol Epitol Atretol | Generic
Purepac Warner-Chilcott Brand NovartisAthenaNeurologica | Pregnancy, children, elderly, renal failure, liver insufficiency | Fatigue, drowsiness, diplopia, nystagmus, nausea. Sedation may occur for the first few days of therapy or following dosage increase. Instigate at lowest possible dosage, increase gradually to level of greatest benefit and fewest side effects. | Properties not fully understood. Blocks use-dependent sodium channels, inhibiting sustained repetitive firing. Reduces post-tatanic potentiation of synaptic transmissions in spinal cord. Pain relief associated with blockade of synaptic transmission in trigeminal nucleus.Metabolized in liver, excreted in urine and feces.Monitor: hemoglobin levels, liver function, CBC, serum carbamazepine concentrations. |
Clonazepam Klonopin | Generic
Novopharm Brand Roche | Abrupt discontinuation is to be avoided | Confusion, depression, dizziness, drowsiness, fatigue, headache, mania, nightmares, psychological dependence, restlessness, tremor, vertigo, withdrawal | Benzodiazepine as anticonvulsant agent. Causes CNS depression. Block cortical and limbic arousal that occurs following stimulation of reticular pathways.Metabolized in liver, excreted in liver. |
Cromolyn sodium
Nasalcrom Others, as listed above in part one | Brand
Fisons Bausch & Lomb WarrickEtc. | Acute bronchospasm, cardiac disease, coronary artery disease, contact lens use (opthalmic solution) | Bronchospasm, cough, diarrhea, headache, lactose intolerance, nasal irritation, nausea, vomiting, hoarseness. Do not share product with other people. | Works at surface of mast cell to inhibit degranulation, preventing release of histamine. May reduce inflammation by inhibiting calcium influx, reduce hyperactivity of bronchi, inhibiting asthmatic response to cold air, allergens, environmental pollutants, or exercise |
Gabapentin
Neurontin | Generic
Not available Brand Parke-Davis | Pregnancy, driving, operating machinery, elderly, renal impairmentAvoid us of antacids | Amnesia, anorexia, anxiety, appetite stimulation, back pain, blurred vision, constipation, depression, diplopia, dizziness, drowsiness, fatigue, irritability, nystagmus, tremor, vertigo | Exact action unknown, appears to interact with cortical neurons at auxiliary subunits of voltage-sensitive calcium channels. Not metabolized, excreted in urine. Monitor: WBC |
Mometasone
NasonexElocon | Generic
Not available Brand Schering corp. | Children, fungal infections, glaucoma, infection, nasal trauma, pregnancy, viral infection, visual disturbance | Acmeiform rash, conjunctivitis, bronchospasm, cough, diarrhea, heavy menstrual bleeding, headache, impaired wound healing, rhinitis, sinusitis, skin irritation | Reduces allergic response of mast cells involved in allergic response. Reduces inflammation and edema. Inhibits release of histamine. Synthetic corticosteroid with anti-inflammatory, antiprurtic, vasoconstrictive properties. |
Phenytoin
Dilantin | Generic
Mylan Alpharma UDL Labs. Elinks-Sinn Brand Parke-Davis | Alcoholism, diabetes mellitus, elderly, fever, hematological disease, pregnancy, renal impairment, thyroid disease | Abdominal pain, anorexia, aplastic anemia, bullous rash, coma, constipation, dizziness, drowsiness, injection site reaction, jaundice, nausea, vomiting, nystagmus | Elevates seizure threshold and/or limits spread of seizure discharge. Limits spread of seizure activity, reduces seizure propagation. Mediated through effect on sodium channels on neuronal cell membrane. Less sedating than phenobarbital. Used to manage grand mal seizures and partial, psychomotor seizures. Used alone or in combination with phenobarbital or other anticonvulsants. Monitor: CBC, LFTs, MCV, serum albumin, serum phenytoin concentrations. Take with food. |
Propranolol
Inderal Betachron | Generic
Geneva Inwood Lederle Sidmak Brand Wyeth-Ayerst Inwood Labs. | Asthma, bronchitis, depression, elderly, emphysema, heart failure, pregnancy, angina, abrupt discontinuation, surgery (interacts with anesthesia drugs) | Diarrhea, fatigue, heart failure, hypoglycemia, libido decrease, muskoskeletal pain, nausea, vomiting, nightmares. | Beta blocker, competes with adrenergic neurotransmitters. |
Topiramate
Topamax | Generic
Not available Brand Ortho-McNeil | Abrupt discontinuation, children, dialysis, driving, operating machinery, pregnancy, renal disease/ failure/impairment | Abdominal pain, agitation, anorexia, anxiety, aphasia, back pain, confusion, constipation, depression, diplopia, dizziness, drowsiness, menstrual irregularity, fatigue, sinusitis, tremor, visual impairment, weight loss | Exact mechanism unknown. May block spread of seizures, rather than raise seizure threshold. May block voltage-sensitive sodium channels. Derived from naturally occurring monosaccharide D-fructose. Has long duration of action and narrow therapeutic range. Not metabolized, excreted unchanged in urine. |
Trileptal Oxycarbazepine | Generic Not available Brand
| | | |
Zonisamide Zonegran | Generic Not available Brand Elan Pharma | Abrupt discontinuation, dehydration, driving, operating machinery, pregnancy, renal disease/failure/impairment, sulfonamide hypersensitivity | Abdominal pain, agitation, anxiety, confusion, constipation, depression, diarrhea, diplopia, dizziness, drowsiness, fatigue, headache, insomnia, irritability nausea, vomiting, nystagmus, psychomotor impairment, rash, rhinitis, weight loss.Additional notes: ataxia, psychosis, speech impairment | Exact mechanism unknown. Appears to exhibit a dual mechanism of action as anticonvulsant by stopping spread of seizures and suppressing their focus. Acts at sodium and calcium channels. May block sodium channels and reduce voltage-dependent, transit-inward currents. Stabilizes neuronal membranes and suppresses neuronal hypersynchronization. Sulfonamide. Metabolized by acetylation and reduction, excreted in urine. Monitor: CBC, LFTs, serum creatinine/BUN, urinalysis. |