Rocky Mountain Juniper:
The Paiute Indians drank a tea of the terminal twigs of Rocky Mountain Juniper in the treatment of syphilis.
Great Lobelia:
The scientific name of the great lobelia, siphilitica, indicates that it was widely used to treat this disease. The Iroquois in the Mohawk Valley of New York used a root decoction to treat syphilis as did English physicians of the early 1800s. Dr. Millspaugh offers an interesting theory as to why the plant failed to effect a cure when employed in Europe:
The natives of North America are said to have held this plant a secret in the cure of syphilis, until it was purchased from them .... and introduced ... as a drug of great repute in that disease. European physicians, however, failed to cure with it, and finally cast it aside, though Linnaeus, thinking it justified its Indian reputation, gave the species its distinctive name, syphilitica. The cause of failure may be the fact that the aborigines did not trust to the plant alone, but always used it in combination with may-apple roots (Podophyllum peltatum), the bark of the wild cherry (Prunus Virginica), and dusted the ulcers with the powdered bark of New Jersey tea (Ceanothus Americanus). Another chance of failure lay in the volatility of its active principle, as the dried herb was used.
Pine:
The Fox and Chippewa boiled the inner bark of pine and drank large quanities of the resulting liquid to cure gonorrhea.
Wild Rose:
The Mescalero Apaches boiled wild rose buds and imbibed the resulting tea to cure gonorrhea.
Slenderleaf Skeleton Plant:
A decoction of the whole slenderleaf skeleton plant was drunk by tribes of the Southwest in the treatment of syphilis.
Sumac:
Either the smooth upland sumac or the mountain sumac was used to treat the external sores of gonorrhea by the Chippewas of Minnesota and the Thompsons of British Columbia.
Although it is not clear which plant was employed, the preparation consisted of the boiled stems and roots in water. About one pint of the decoction was taken in a single dose; this was often not repeated through the course of the disease. The Thompsons were aware of the dangerous properties of these species, and they considered this remedy poisonous in large doses.
The use of mountain sumac by the American Indians was noted in 1806 in the Journals of the Lewis and Clark Expedition:
The Chippawas use a decoction of the root ... of a species of Sumac common to the Atlantic States and to this country near and on the western side of the Rocky Mountains ... These decoctions are drank freely and without limitation.
The same decoctions are used also in cases of the Gonnarea and are effecatious and sovereign. Not-withstanding that this disorder does exist among the indians on the Columbia yet it is witnessed in but few individuals, high up the river, or at least the males who are always sufficiently exposed to the observation or inspection of the physician.
In my whole route down this river I did not see more than two or three with Gonnarea and about double that number with the pox.
Mountain sumac is easily distinguished from other sumacs by the winged shape of its leaf stalk between the leaflets.
Thistle:
The Zunis steeped the whole thistle plant overnight in cold water and drank the infusion three times daily. Men were required to run after each dose of the medicine to encourage sweating and they were then wrapped in blankets. This treatment often caused nausea and vomiting.